An Unusual Two‐Step Hydrolysis of Nerve Agents by a Nanozyme
Sign Up to like & getrecommendations! Published in 2018 at "ChemCatChem"
DOI: 10.1002/cctc.201801220
Abstract: Organophosphate‐based nerve agents irreversibly inhibit acetylcholinesterase enzyme, leading to respiratory failure, paralysis and death. Several organophosphorus hydrolases are capable of degrading nerve agents including pesticides and insecticides. Development of stable artificial enzymes capable of hydrolysing… read more here.
Keywords: nerve agents; hydrolysis nerve; unusual two; two step ... See more keywords
Phosphonylated tyrosine and lysine residues as biomarkers of local exposure of human hair to the organophosphorus nerve agents sarin and VX.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3459
Abstract: We herein present for the first time a micro liquid chromatography-electrospray ionization high-resolution tandem-mass spectrometry (μLC-ESI MS/HR MS) procedure to detect phosphonylated tyrosine (Tyr) and lysine (Lys) residues obtained from human hair exposed to organophosphorus… read more here.
Keywords: hair; nerve agents; human hair; phosphonylated tyrosine ... See more keywords
Contaminated disposable rubber gloves as evidence samples after a chemical attack with nerve agents.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3468
Abstract: Nerve agents have been used recently in the Syrian civil war. Collecting relevant samples for retrospective identification of an attack is often problematic. The article deals with the possibility of using of contaminated gloves as… read more here.
Keywords: disposable rubber; identification; evidence; attack ... See more keywords
An OPAA enzyme mutant with increased catalytic efficiency on the nerve agents sarin, soman, and GP.
Sign Up to like & getrecommendations! Published in 2018 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.11.001
Abstract: The wild-type OPAA enzyme has relatively high levels of catalytic activity against several organophosphate G-type nerve agents. A series of mutants containing replacement amino acids at the OPAA Y212, V342, and I215 sites showed several… read more here.
Keywords: catalytic efficiency; nerve agents; opaa enzyme; sarin soman ... See more keywords
Environmental exposure to organophosphorus nerve agents.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.09.004
Abstract: Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and… read more here.
Keywords: nerve agents; organophosphorus nerve; exposure organophosphorus; exposure ... See more keywords
SERS-based ultrasensitive detection of organophosphorus nerve agents via substrate's surface modification.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2016.10.049
Abstract: Highly efficient detection of the organicphosphor nerve agents such as sarin and soman, based on surface enhanced Raman scattering (SERS) effect, has been in challenge due to their weak adsorption property on coin metals. In… read more here.
Keywords: detection; nerve agents; surface; sers based ... See more keywords
Translational research on chemical nerve agents
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of disease"
DOI: 10.1016/j.nbd.2018.11.020
Abstract: This special issue will describe cutting-edge translational research on the development of safe and effective therapeutics for treating exposure to toxic chemical threat agents that target the nervous system. These studies are supported by the… read more here.
Keywords: research; research chemical; nerve agents; chemical ... See more keywords
Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108111
Abstract: The recent advancements in crystallography and kinetics studies involving reactivation mechanism of acetylcholinesterase (AChE) inhibited by nerve agents have enabled a new paradigm in the search for potent medical countermeasures in case of nerve agents… read more here.
Keywords: ache; acetylcholinesterase; nerve agents; reactivation ... See more keywords
Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.01.004
Abstract: The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice on assistance and protection in relation to the Chemical Weapons Convention. In this, the first of several… read more here.
Keywords: chemical weapons; nerve agents; advisory board; scientific advisory ... See more keywords
Protein adduct binding properties of tabun-subtype nerve agents after exposure in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.12.014
Abstract: Upon entering the body, nerve agents can bind active amino acid residues to form phosphonylated adducts. Tabun derivatives (O-alkyl-N,N-dialkyl phosphoroamidocyanidates) have strikingly different structural features from other G-series nerve agents, such as sarin and soman.… read more here.
Keywords: properties tabun; tabun derivatives; binding properties; nerve agents ... See more keywords
Visual and Rapid Detection of Nerve Agent Mimics in Gas and Solution Phase by a Simple Fluorescent Probe.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04891
Abstract: Chemical nerve agents are highly toxic organophosphorus compounds that are easy to obtain and can be utilized by terrorists to threaten homeland security and human safety. Those organophosphorus nerve agents contain nucleophilic ability that can… read more here.
Keywords: nerve; detection; nerve agents; solution ... See more keywords