Analgesic effects of nerve growth factor‐directed monoclonal antibody on diabetic neuralgia in an animal model
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13410
Abstract: Current treatment options for diabetic neuralgia are limited and unsatisfactory. Tanezumab, a monoclonal antibody that blocks nerve growth factor (NGF) signaling, has been shown to be effective in relieving the clinical symptoms of osteoarthritis pain,… read more here.
Keywords: monoclonal antibody; diabetic neuralgia; nerve growth; growth factor ... See more keywords
Controlling Nerve Growth with an Electric Field Induced Indirectly in Transparent Conductive Substrate Materials
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DOI: 10.1002/adhm.201800473
Abstract: Innovative neurostimulation therapies require improved electrode materials, such as poly(3,4-ethylenedioxythiophene) (PEDOT) polymers or IrOx mixed ionic-electronic conductors and better understanding of how their electrochemistry influences nerve growth. Amphibian neurons growing on transparent films of electronic… read more here.
Keywords: nerve growth; stimulation; controlling nerve; growth electric ... See more keywords
Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.26606
Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non-opioid pain relief. To… read more here.
Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords
Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti‐NGF monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26706
Abstract: Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti‐NGF monoclonal antibodies (mAbs) that function by antagonizing NGF downstream signaling are leading drug candidates for non‐opioid pain relief. To… read more here.
Keywords: nerve growth; pro region; anti ngf; epitope ... See more keywords
Pleiotropic activity of nerve growth factor in regulating cardiac functions and counteracting pathogenesis
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13138
Abstract: Cardiac innervation density generally reflects the levels of nerve growth factor (NGF) produced by the heart—changes in NGF expression within the heart and vasculature contribute to neuronal remodelling (e.g. sympathetic hyperinnervation or denervation). Its synthesis… read more here.
Keywords: growth factor; heart; nerve growth; pleiotropic activity ... See more keywords
Nerve growth factor sensitizes nociceptors to C-fiber selective.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pain"
DOI: 10.1002/ejp.1678
Abstract: BACKGROUND Intradermal injection of 1 µg nerve growth factor (NGF) causes sustained nociceptor sensitization. Slowly depolarizing electrical current preferentially activates C-nociceptors. METHODS We explored the differential contribution of A-delta and C-nociceptors in NGF sensitized skin… read more here.
Keywords: growth factor; stimulation; nerve growth;
Ectopic nerve growth factor prevents proliferation in glioma cells by senescence induction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27430
Abstract: The neurotrophin nerve growth factor (NGF) affects survival, regulation and differentiation of both central and peripheral nervous system neurons. NGF exerts its effects primarily through tropomyosin receptor kinase A (TrkA), inducing a cascade of tyrosine… read more here.
Keywords: growth factor; nerve growth; glioma;
Nerve growth factor receptors in equine synovial membranes vary with osteoarthritic disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.25382
Abstract: Nerve growth factor (NGF) is a neurotrophin that has been implicated in pain signaling, apoptosis, inflammation and proliferation. The resultant effects depend on interaction with two different receptors; tyrosine kinase A (TrkA) and p75NTR. NGF… read more here.
Keywords: osteoarthritic disease; synovial membranes; disease; nerve growth ... See more keywords
Synergistic effect of nanofat and mouse nerve‐growth factor for promotion of sensory recovery in anterolateral thigh free flaps
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DOI: 10.1002/sctm.20-0226
Abstract: Anterolateral thigh (ALT) free flaps are widely used for reconstruction, but poor sensory recovery of the flap tissue can cause unsatisfactory outcomes and poor function. Adipose‐derived mesenchymal stem cells (ADSCs) promote neural regeneration, but the… read more here.
Keywords: recovery; nerve growth; anterolateral thigh; sensory recovery ... See more keywords
The First and Last Time I Met Rita Levi-Montalcini: From the Insect Neurotrophic Factor to the Nerve Growth Factor Clinical Application : RLM and the Discovery of Two Neurotrophic Factors.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-74046-7_2
Abstract: The neurotrophic factor nerve growth factor (NGF) has been discovered in the 1950s by Rita Levi-Montalcini, first in a neoplastic tissue and, later, in the mouse salivary gland (see 1A). Levi-Montalcini characterized its action in… read more here.
Keywords: rita levi; nerve growth; growth factor; neurotrophic factor ... See more keywords
Effect of Nerve Growth Factor on Neural Differentiation of Mouse Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-017-3686-1
Abstract: The cholinergic, GABAergic, and catecholaminergic neurons derived from mouse embryonic stem cells in a culture medium supplemented with recombinant NGF were phenotyped and scored. NGF stimulated generation of neurons, but not neuronal progenitors from embryonic… read more here.
Keywords: nerve growth; mouse embryonic; embryonic stem; stem cells ... See more keywords