N6‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
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DOI: 10.1002/advs.201902402
Abstract: Abstract Nerve injury‐induced change in gene expression in primary sensory neurons of dorsal root ganglion (DRG) is critical for neuropathic pain genesis. N6‐methyladenosine (m6A) modification of RNA represents an additional layer of gene regulation. Here,… read more here.
Keywords: sensory neurons; neuropathic pain; nerve injury; primary sensory ... See more keywords
Neuronal C‐Reactive Protein/FcγRI Positive Feedback Proinflammatory Signaling Contributes to Nerve Injury Induced Neuropathic Pain
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DOI: 10.1002/advs.202205397
Abstract: Neuropathic pain is difficult to treat in clinical practice, and the underlying mechanisms are insufficiently elucidated. Previous studies have demonstrated that the neuronal Fc‐gamma‐receptor type I (FcγRI) of the dorsal root ganglion (DRG) mediates antigen‐specific… read more here.
Keywords: nerve injury; neuropathic pain; pain; reactive protein ... See more keywords
Perineural application of resiniferatoxin on uninjured L3 and L4 nerves completely alleviates thermal and mechanical hypersensitivity following L5 nerve injury in rats
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DOI: 10.1002/cne.24884
Abstract: Fifth lumbar (L5) nerve injury in rats causes neuropathic pain manifested with thermal and mechanical hypersensitivity in the ipsilateral hind paw. This study aimed to determine whether the elimination of unmyelinated primary afferents of the… read more here.
Keywords: thermal mechanical; mechanical hypersensitivity; application; uninjured nerves ... See more keywords
Schwann cells regulate sensory neuron gene expression before and after peripheral nerve injury
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DOI: 10.1002/glia.23325
Abstract: Sensory neurons in the PNS demonstrate substantial capacity for regeneration following injury. Recent studies have identified changes in the transcriptome of sensory neurons, which are instrumental for axon regeneration. The role of Schwann cells (SCs)… read more here.
Keywords: sclrp1 mice; nerve injury; injury; expression ... See more keywords
Recombinant interleukin‐4 alleviates mechanical allodynia via injury‐induced interleukin‐4 receptor alpha in spinal microglia in a rat model of neuropathic pain
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DOI: 10.1002/glia.23340
Abstract: Glial cells play important roles in the development and maintenance of neuropathic pain. In particular, activated microglia in the spinal cord facilitate the hyper‐excitability of dorsal horn neurons after peripheral nerve injury via pro‐inflammatory molecules.… read more here.
Keywords: spinal microglia; injury induced; neuropathic pain; nerve injury ... See more keywords
Overexpression of P2X4 receptor in Schwann cells promotes motor and sensory functional recovery and remyelination via BDNF secretion after nerve injury
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DOI: 10.1002/glia.23527
Abstract: Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including… read more here.
Keywords: schwann; schwann cells; remyelination; p2x4r ... See more keywords
Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury
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DOI: 10.1002/glia.23959
Abstract: Peripheral nerve section with subsequent disconnection of motor neuron (MN) cell bodies from their skeletal muscle targets leads to a rapid reactive response involving the recruitment and activation of microglia. In addition, the loss of… read more here.
Keywords: synaptic terminals; disruption; motor; nerve injury ... See more keywords
Sex‐specific transcriptome of spinal microglia in neuropathic pain due to peripheral nerve injury
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DOI: 10.1002/glia.24133
Abstract: Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by activation in glial cells in various pain‐related regions within the central nervous system. Recent studies have suggested a sexually dimorphic role of… read more here.
Keywords: spinal microglia; sex; neuropathic pain; pain ... See more keywords
Electrical stimulation accelerates Wallerian degeneration and promotes nerve regeneration after sciatic nerve injury
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DOI: 10.1002/glia.24309
Abstract: Following peripheral nerve injury (PNI), Wallerian degeneration (WD) in the distal stump can generate a microenvironment favorable for nerve regeneration. Brief low‐frequency electrical stimulation (ES) is an effective treatment for PNI, but the mechanism underlying… read more here.
Keywords: nerve injury; regeneration; degeneration; nerve regeneration ... See more keywords
Curcumin slow‐release membrane promotes erectile function and penile rehabilitation in a rat model of cavernous nerve injury
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DOI: 10.1002/term.3334
Abstract: Male erectile dysfunction (ED) caused by cavernous nerve injury is a common complication of pelvic surgery, radiotherapy, transurethral surgery or other operations. However, clinical treatment for iatrogenic or traumatic male ED is difficult and not… read more here.
Keywords: release membrane; curcumin; slow release; cavernous nerve ... See more keywords
Face sensorimotor cortex undergoes neuroplastic changes in a rat model of trigeminal neuropathic pain
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DOI: 10.1007/s00221-018-5226-2
Abstract: Trigeminal nerve injury can result in neuropathic pain behavior and alterations in motor function, but it is unclear if such injury produces neuroplastic alterations in face sensorimotor cortex that could contribute to the alterations in… read more here.
Keywords: sensorimotor cortex; cortex; face sensorimotor; nerve injury ... See more keywords