Nesfatin-1 protects against diabetic cardiomyopathy in the streptozotocin-induced diabetic mouse model via the p38-MAPK pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2066748
Abstract: ABSTRACT Nesfatin-1 is a novel anorexigenic peptide that possesses antihyperglycemic and cardiovascular effects. We hypothesized that nesfatin-1 has a beneficial protective effect against diabetic cardiomyopathy (DC). We investigated the therapeutic effect of nesfatin-1 on diabetes-associated… read more here.
Keywords: diabetic mouse; nesfatin; induced diabetic; p38 mapk ... See more keywords
Increased serum nesfatin-1 levels in patients with acromegaly
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DOI: 10.1097/md.0000000000022432
Abstract: Abstract Nesfatin-1 was identified as a satiety factor involved in the regulation of metabolism. Altered levels of circulating nesfatin-1 had been observed in a variety of diseases characterized by energy imbalance. However, there was no… read more here.
Keywords: nesfatin levels; patients acromegaly; serum nesfatin; nesfatin ... See more keywords
Evaluation of interactions between nesfatin-1 and B lymphocytes
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DOI: 10.1152/physiol.2023.38.s1.5731653
Abstract: The function of nesfatin-1, corresponding to the nucleobindin2 (NUCB2) precursor, was first identified in the hypothalamic nuclei, and was reported to be potently anorexigenic (Oh-I et al. 2006). More recently it has been shown that… read more here.
Keywords: nesfatin lymphocytes; cell; nesfatin; physiology ... See more keywords
Nesfatin-1 Suppresses Fish Reproductive Axis and Gonadal Steroidogenesis.
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DOI: 10.1530/rep-20-0068
Abstract: Nesfatin-1 is a naturally occurring orphan ligand in fish and mammals. Research in our lab resulted in the identification of an inhibitory role for nesfatin-1 on pituitary hormones (goldfish) and oocyte maturation (zebrafish). The present… read more here.
Keywords: fish reproductive; suppresses fish; reproductive axis; nesfatin ... See more keywords
Ghrelin Receptor Is Required for the Effect of Nesfatin-1 on Glucose Metabolism
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DOI: 10.3389/fendo.2018.00633
Abstract: Studies of nesfatin-1 in glucose metabolism have become a topic of interest recently, however, the specific receptor for nesfatin-1 has not yet been identified. Some studies hinted at a connection between nesfatin-1 and the ghrelin… read more here.
Keywords: nesfatin glucose; glucose metabolism; nesfatin; receptor ... See more keywords
Hypothalamic Nesfatin-1 Resistance May Underlie the Development of Type 2 Diabetes Mellitus in Maternally Undernourished Non-obese Rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.828571
Abstract: Intrauterine growth retardation (IUGR) poses a high risk for developing late-onset, non-obese type 2 diabetes (T2DM). The exact mechanism underlying this phenomenon is unknown, although the contribution of the central nervous system is recognized. The… read more here.
Keywords: nesfatin resistance; non obese; hypothalamic nesfatin; nesfatin ... See more keywords
Nesfatin-1 Stimulates CCL2-dependent Monocyte Migration And M1 Macrophage Polarization: Implications For Rheumatoid Arthritis Therapy
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DOI: 10.7150/ijbs.77987
Abstract: Rheumatoid arthritis (RA) is a prototypic inflammatory disease, characterized by the infiltration of proinflammatory cytokines into the joint synovium and the migration of mononuclear cells into inflammatory sites. The adipokine nesfatin-1 is linked to inflammatory… read more here.
Keywords: monocyte migration; rheumatoid arthritis; expression; nesfatin ... See more keywords
The Performance of Nesfatin-1 in Distinguishing Irritable Bowel Syndrome Presenting Predominantly with Diarrhea from Celiac Disease.
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DOI: 10.7754/clin.lab.2020.191215
Abstract: BACKGROUND We hypothesized that nesfatin-1, an anti-inflammatory peptide, could be used as a non-invasive diagnostic tool in the identification of celiac disease (CD) and irritable bowel syndrome presenting predominantly with diarrhea (IBS-D). METHODS Thirty-five patients… read more here.
Keywords: nesfatin; healthy controls; celiac disease; irritable bowel ... See more keywords