Net‐benefit regression with censored cost‐effectiveness data from randomized or observational studies
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9486
Abstract: Cost‐effectiveness analysis is an essential part of the evaluation of new medical interventions. While in many studies both costs and effectiveness (eg, survival time) are censored, standard survival analysis techniques are often invalid due to… read more here.
Keywords: censored cost; cost; cost effectiveness; net benefit ... See more keywords
Individualized Net Benefit estimation and meta‐analysis using generalized pairwise comparisons in N‐of‐1 trials
Sign Up to like & getrecommendations! Published in 2023 at "Statistics in Medicine"
DOI: 10.1002/sim.9648
Abstract: The Net Benefit (Δ) is a measure of the benefit‐risk balance in clinical trials, based on generalized pairwise comparisons (GPC) using several prioritized outcomes and thresholds of clinical relevance. We extended Δ to N‐of‐1 trials,… read more here.
Keywords: generalized pairwise; individualized net; net benefit; pairwise comparisons ... See more keywords
Panic in the Pandemic: When Should Kidney Transplant Programs Close?
Sign Up to like & getrecommendations! Published in 2021 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2021.02.017
Abstract: Background Pandemics greatly interfere with overall health care delivery as resources are diverted to combat the crisis. Kidney transplantation programs were closed temporarily during the COVID-19 pandemic. Given the critical shortage of organs, their short… read more here.
Keywords: kidney transplant; life; net benefit; kidney ... See more keywords
Net benefit of diagnostic tests for multistate diseases: an indicator variables approach.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biopharmaceutical statistics"
DOI: 10.1080/10543406.2023.2169928
Abstract: A limitation of the common measures of diagnostic test performance, such as sensitivity and specificity, is that they do not consider the relative importance of false negative and false positive test results, which are likely… read more here.
Keywords: diagnostic tests; alzheimer disease; etiology; net benefit ... See more keywords
The benefit-risk balance for biological agents in juvenile idiopathic arthritis: a meta-analysis of randomized clinical trials.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa170
Abstract: OBJECTIVE To assess the net benefit of biological agents (BA) used in JIA. METHODS We systematically searched databases up to March 2019 for randomized controlled trials (RCT) performed in JIA disease. Separate random-effects meta-analyses were… read more here.
Keywords: meta analysis; risk; net benefit; jia ... See more keywords
Net benefit index: Assessing the influence of a biomarker for individualized treatment rules.
Sign Up to like & getrecommendations! Published in 2020 at "Biometrics"
DOI: 10.1111/biom.13373
Abstract: One central task in precision medicine is to establish individualized treatment rules (ITRs) for patients with heterogeneous responses to different therapies. Motivated from a randomized clinical trial for Type 2 diabetic patients on a comparison… read more here.
Keywords: individualized treatment; index; treatment rules; biomarker ... See more keywords
Robust statistical inference for matched win statistics
Sign Up to like & getrecommendations! Published in 2022 at "Statistical Methods in Medical Research"
DOI: 10.1177/09622802221090761
Abstract: As alternatives to the time-to-first-event analysis of composite endpoints, the win statistics, that is, the net benefit, the win ratio, and the win odds have been proposed to assess treatment effects, using a hierarchy of… read more here.
Keywords: inference matched; win statistics; net benefit; matched win ... See more keywords
Rejoinder to Dr Vickers
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DOI: 10.1177/17407745211068548
Abstract: We thank Dr Vickers for his thoughtful commentary. Dr Vickers argues that if a benefit–harm metric includes absolutely every aspect of the decision, then there is no clinically relevant difference, and even for the smallest… read more here.
Keywords: benefit harm; net benefit; evidence; benefit ... See more keywords
Liver Transplantation for T2 Hepatocellular Carcinoma during the COVID-19 Pandemic: A Novel Model Balancing Individual Benefit against Healthcare Resources
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13061416
Abstract: Simple Summary Using Italian national data from more than 8000 patients, we proposed a novel model calculating the net benefit of liver transplantation (individual benefit minus harm to others on the waiting list) in T2… read more here.
Keywords: benefit; hcc patients; net benefit; liver transplantation ... See more keywords