NETosis - Dr. Jekyll and Mr. Hyde in inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Biomedicine"
DOI: 10.1016/j.jab.2017.10.002
Abstract: Abstract Neutrophils play an important role as the central mediators of the innate immune defence response, providing the first line of host protection. It was shown that these cells can trap and kill various microorganisms… read more here.
Keywords: jekyll hyde; netosis; hyde inflammation; netosis jekyll ... See more keywords
NETosis in ischemic/reperfusion injuries: An organ-based review.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120158
Abstract: Neutrophil extracellular trap (NETosis), the web-like structures induced by neutrophil death, is an important inflammatory mechanism of the immune system leading to reactive oxygen species production/coagulopathy, endothelial dysfunction, atherosclerosis, and ischemia. NETosis exerts its role… read more here.
Keywords: netosis ischemic; injuries organ; reperfusion injuries; netosis ... See more keywords
Hydrogen sulfide primes diabetic wound to close through inhibition of NETosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.10.013
Abstract: Diabetes-induced neutrophil NETosis impairs wound healing through neutrophil extracellular traps (NETs). Reactive oxygen species (ROS)-triggered activation of mitogen-activated protein kinase (MAPK) ERK1/2 and p38 is involved in NETosis. Hydrogen sulfide (H2S), an endogenous signaling molecule,… read more here.
Keywords: netosis; activation; diabetic wound; erk1 p38 ... See more keywords
A potential role of neutrophil extracellular traps (NETs) in kidney acute antibody mediated rejection.
Sign Up to like & getrecommendations! Published in 2020 at "Transplant immunology"
DOI: 10.1016/j.trim.2020.101286
Abstract: BACKGROUND The aim of this study was to evaluate neutrophil extracellular traps (NETs) in kidney transplant recipients (KTR) and their potential involvement in acute antibody-mediated rejection (AAMR). METHODS We studied 3 groups: KTR with AAMR… read more here.
Keywords: neutrophil extracellular; netosis; ktr; rejection ... See more keywords
Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis
Sign Up to like & getrecommendations! Published in 2019 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.9b00142
Abstract: The indolylmaleimide (IM) derivative IM-17 shows inhibitory activity against oxidative-stress-induced necrotic cell death and cardioprotective activity in rat ischemia-reperfusion injury models. In order to develop a more potent derivative, we conducted a detailed structure–activity relationship… read more here.
Keywords: indolylmaleimide derivative; ferroptosis netosis; water; netosis ... See more keywords
Gasdermin D inhibitor protects against sepsis
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-020-00084-2
Abstract: 388 | JuNe 2020 | volume 19 An expansion of neutrophils in patients with cancer is usually associated with a poor prognosis. This is thought to be due to the ability of neutrophils to induce… read more here.
Keywords: tumour cells; netosis; gasdermin inhibitor; cell ... See more keywords
Shortening jet-lag recovery
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-020-00085-1
Abstract: 388 | JuNe 2020 | volume 19 An expansion of neutrophils in patients with cancer is usually associated with a poor prognosis. This is thought to be due to the ability of neutrophils to induce… read more here.
Keywords: tumour cells; netosis; shortening jet; cell ... See more keywords
Two-in-one: UV radiation simultaneously induces apoptosis and NETosis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death Discovery"
DOI: 10.1038/s41420-018-0048-3
Abstract: NETosis is a unique form of neutrophil death that differs from apoptosis and necrosis. However, whether NETosis and apoptosis can occur simultaneously in the same neutrophil is unknown. In this paper, we show that increasing… read more here.
Keywords: apoptosis netosis; independent netosis; two one; netosis ... See more keywords
Hippo pathway and NLRP3-driven NETosis in macrophages: Mechanisms of viral pneumoniaaggravation
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02556-z
Abstract: Severe viral infections can precipitate acute lung injury, resulting in significant morbidity and mortality. While NETosis serves as an important defense mechanism against pathogens and viruses, its excessive or dysregulated activation may contribute to pulmonary… read more here.
Keywords: hippo pathway; lung injury; pathway nlrp3; netosis ... See more keywords
Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09160-7
Abstract: Heparin-induced thrombocytopenia/thrombosis (HIT) is a serious immune reaction to heparins, characterized by thrombocytopenia and often severe thrombosis with high morbidity and mortality. HIT is mediated by IgG antibodies against heparin/platelet factor 4 antigenic complexes. These… read more here.
Keywords: heparin; netosis; neutrophil activation; induced thrombocytopenia ... See more keywords
Piezo1 expression in neutrophils regulates shear-induced NETosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51211-1
Abstract: Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore, neutrophil extracellular traps (NETs) are prothrombotic, as they provide a scaffold for platelets and red blood cells to attach… read more here.
Keywords: shear stress; piezo1 expression; activation piezo1; stress ... See more keywords