Aloe-Emodin Targeting FOXC2 Disrupts NETs Formation and EMT-Driven Postoperative Peritoneal Adhesion Through TGF-β1-Smad2/3 Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202511013
Abstract: Postoperative peritoneal adhesion (PPA) develops through TGF‐β1‐driven fibrotic remodeling, characterized by neutrophil extracellular trap (NETs)‐induced aberrant epithelial‐to‐mesenchymal transition (EMT) deposition. Although aloe‐emodin (AE) exhibits anti‐fibrosis potential, its molecular mechanisms remain elusive. Forkhead box protein C2… read more here.
Keywords: smad2 pathway; postoperative peritoneal; tgf smad2; emt ... See more keywords
Importance of Selenoprotein O in Regulating Hmgb1: A New Direction for Modulating ROS-Dependent NETs Formation to Aggravate the Progression of Acute Liver Inflammation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c01956
Abstract: Selenoproteins (Sels) are a class of essential biomolecules that play critical roles in cellular homeostasis. SelO was identified as the preferential source of selenium in the liver, implying its potential as a key regulatory factor… read more here.
Keywords: selo; acute liver; liver inflammation; inflammation ... See more keywords
Neutrophil extracellular traps and neutrophilic dermatosis: an update review
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-023-01787-2
Abstract: Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and… read more here.
Keywords: neutrophil extracellular; extracellular traps; traps neutrophilic; nets formation ... See more keywords
The crucial role of neutrophil extracellular traps and IL-17 signaling in indomethacin-induced gastric injury in mice
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-95880-4
Abstract: The homeostasis of gastric mucosa is extremely delicate. Neutrophils, the most abundant immune cells in human circulation, are regarded crutial in the regulation of gastric mucosal immune response. Non-steroidal anti-inflammatory drugs (NSAIDs) induced gastric injury… read more here.
Keywords: gastric injury; injury; induced gastric; nets formation ... See more keywords
Neutrophil Activation and Netosis Are the Key Drivers of Thrombosis in Heparin-Induced Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-116421
Abstract: Adverse drug effects are common in clinical practice and often have a negative impact on patient safety. Heparin and heparin-derived drugs may induce an immune reaction, termed heparin-induced thrombocytopenia (HIT). HIT is mediated by IgG… read more here.
Keywords: heparin; figure; netosis; nets formation ... See more keywords
Neutrophil extracellular traps are downregulated by glucocorticosteroids in lungs in an equine model of asthma
Sign Up to like & getrecommendations! Published in 2017 at "Respiratory Research"
DOI: 10.1186/s12931-017-0689-4
Abstract: BackgroundSevere neutrophilic asthma is poorly responsive to glucocorticosteroids (GC). Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity of airway obstruction and inflammation in asthma, and were found to be unaffected… read more here.
Keywords: neutrophil extracellular; nets formation; traps downregulated; asthma ... See more keywords
Platelet membrane-coated nanoparticles inhibit platelet activation and neutrophil extracellular traps formation in acute lung injury
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06649-2
Abstract: Platelets play a critical role in the pathophysiology of acute lung injury (ALI) by activating neutrophils and promoting the formation of neutrophil extracellular traps (NETs). Excessive NETs formation exacerbates lung injury by triggering inflammation, impairing… read more here.
Keywords: platelet activation; lung injury; nets formation; platelet ... See more keywords
IgD enhances the release of neutrophil extracellular traps (NETs) via FcδR in rheumatoid arthritis patients.
Sign Up to like & getrecommendations! Published in 2022 at "International immunopharmacology"
DOI: 10.22541/au.164408019.96969408/v1
Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder affecting primarily the joints. Neutrophils and the release of neutrophil extracellular traps (NETs) contribute to the pathogenesis of RA. However, IgD, which was abnormally higher in… read more here.
Keywords: nets formation; release neutrophil; rheumatoid arthritis; igd ... See more keywords
Dexamethasone Inhibits S. aureus-Induced Neutrophil Extracellular Pathogen-Killing Mechanism, Possibly through Toll-Like Receptor Regulation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00060
Abstract: Neutrophils release neutrophil extracellular traps (NETs) in a pathogen-killing process called NETosis. Excessive NETs formation, however, is implicated in disease pathogenesis. Therefore, to understand how NETosis is regulated, we examined the effect of dexamethasone (DXM),… read more here.
Keywords: neutrophil extracellular; netosis; nets formation; aureus induced ... See more keywords
STING regulates NETs formation by activating GSDMD in influenza viral pneumonia
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1598902
Abstract: Background Viral pneumonia is the most common and lethal pandemic disease, but there are no broad-spectrum antiviral drugs with high genetic barriers to resistance. To elucidate the mechanisms of viral pneumonia progression and potential targets… read more here.
Keywords: pneumonia sting; pneumonia; gsdmd; viral pneumonia ... See more keywords
Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer"
DOI: 10.7150/jca.24238
Abstract: Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular… read more here.
Keywords: cell carcinoma; oral squamous; squamous cell; inflammation ... See more keywords