Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis
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DOI: 10.1038/s41423-020-00591-7
Abstract: During sepsis, neutrophil activation induces endothelial cell (EC) dysfunction partly through neutrophil extracellular trap (NET) release. The triggering receptor expressed on myeloid cell-1 (TREM-1) is an orphan immune receptor that amplifies the inflammatory response mediated… read more here.
Keywords: potentiation nets; activation; nets release; inhibition trem ... See more keywords
Zinc Supplementation Modulates NETs Release and Neutrophils’ Degranulation
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DOI: 10.3390/nu13010051
Abstract: Zinc plays an important physiological role in the entire body, especially in the immune system. It is one of the most abundant microelements in our organism and an essential component of enzymes and antibacterial proteins.… read more here.
Keywords: zinc; nets release; zinc supplementation; neutrophils degranulation ... See more keywords