Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14224-9
Abstract: Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects… read more here.
Keywords: network; network colorectal; cells expressing; colorectal cancer ... See more keywords
Molecular Network of Colorectal Cancer and Current Therapeutic Options
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.852927
Abstract: Colorectal cancer (CRC), a leading cause of cancer-related mortalities globally, results from the accumulation of multiple genetic and epigenetic alterations in the normal colonic and rectum epithelium, leading to the progression from colorectal adenomas to… read more here.
Keywords: molecular network; cancer current; cancer; network colorectal ... See more keywords