Network medicine and type 2 diabetes mellitus: insights into disease mechanism and guide to precision medicine
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine"
DOI: 10.1007/s12020-019-02042-4
Abstract: Understanding the genomic basis of type 2 diabetes mellitus is a major challenge. Simple genome-wide association studies (GWAS) have identified ~250 loci that link to the phenotype; however, the great majority have tiny effect size… read more here.
Keywords: medicine; network; network medicine; disease ... See more keywords
Drug repositioning for psychiatric and neurological disorders through a network medicine approach
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-0827-5
Abstract: Psychiatric and neurological disorders (PNDs) affect millions worldwide and only a few drugs achieve complete therapeutic success in the treatment of these disorders. Due to the high cost of developing novel drugs, drug repositioning represents… read more here.
Keywords: medicine; drug repositioning; psychiatric neurological; network medicine ... See more keywords
Network medicine in ovarian cancer: topological properties to drug discovery.
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac085
Abstract: Network medicine provides network theoretical tools, methods and properties to study underlying laws governing human interactome to identify disease states and disease complexity leading to drug discovery. Within this framework, we investigated the topological properties… read more here.
Keywords: medicine; topological properties; network; network medicine ... See more keywords
Network Medicine In Cardiovascular Research.
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular research"
DOI: 10.1093/cvr/cvaa321
Abstract: The ability to generate multi-omics data coupled with deeply characterizing the clinical phenotype of individual patients promises to improve understanding of complex cardiovascular pathobiology. There remains an important disconnection between the magnitude and granularity of… read more here.
Keywords: cardiovascular research; medicine; medicine cardiovascular; network medicine ... See more keywords
Multiomics Network Medicine Approaches to Precision Medicine and Therapeutics in Cardiovascular Diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"
DOI: 10.1161/atvbaha.122.318731
Abstract: Cardiovascular diseases (CVD) are the leading cause of death worldwide and display complex phenotypic heterogeneity caused by many convergent processes, including interactions between genetic variation and environmental factors. Despite the identification of a large number… read more here.
Keywords: network; precision medicine; network medicine; medicine ... See more keywords
Deciphering the Basis of Molecular Biology of Selected Cardiovascular Diseases: A View on Network Medicine
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911421
Abstract: Cardiovascular diseases are the leading cause of death across the world. For decades, researchers have been studying the causes of cardiovascular disease, yet many of them remain undiscovered or poorly understood. Network medicine is a… read more here.
Keywords: disease; cardiovascular diseases; network medicine; medicine ... See more keywords