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Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.05.008
Abstract: Protein interaction networks provide a powerful framework for identifying genes causal for complex genetic diseases. Here, we introduce a general framework, uKIN, that uses prior knowledge of disease-associated genes to guide, within known protein-protein interaction…
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Keywords:
information;
network;
guided network;
network propagation ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46566
Abstract: Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in diverse cellular processes and biological functions. Exploring the functions associated with lncRNAs may help provide insight into their underlying biological mechanisms. The current…
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Keywords:
lncrnas interest;
pathways influenced;
method;
network propagation ... See more keywords
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Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty247
Abstract: Motivation Network propagation has been widely used to aggregate and amplify the effects of tumor mutations using knowledge of molecular interaction networks. However, propagating mutations through interactions irrelevant to cancer leads to erosion of pathway…
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Keywords:
propagation;
tumors supervised;
network;
supervised network ... See more keywords
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Published in 2017 at "IEEE Transactions on Antennas and Propagation"
DOI: 10.1109/tap.2017.2734170
Abstract: This communication presents the results of the first field measurement campaign to characterize the large- and small-scale propagation statistics of the peer-to-peer wireless link in an operating petroleum refinery. Results for ground level transmission and…
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Keywords:
propagation;
petroleum refinery;
network propagation;
refinery mesh ... See more keywords
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Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0740
Abstract: Combination therapies are commonly used to treat patients with complex diseases that respond poorly to single-agent therapies. In vitro high-throughput drug screening is a standard method for preclinical prioritization of synergistic drug combinations, but it…
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Keywords:
synergy;
network propagation;
drug;
drug synergy ... See more keywords
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Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1009161
Abstract: Network propagation refers to a class of algorithms that integrate information from input data across connected nodes in a given network. These algorithms have wide applications in systems biology, protein function prediction, inferring condition-specifically altered…
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Keywords:
propagation;
multi omics;
network;
network propagation ... See more keywords