uKIN Combines New and Prior Information with Guided Network Propagation to Accurately Identify Disease Genes.
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.05.008
Abstract: Protein interaction networks provide a powerful framework for identifying genes causal for complex genetic diseases. Here, we introduce a general framework, uKIN, that uses prior knowledge of disease-associated genes to guide, within known protein-protein interaction… read more here.
Keywords: information; network; guided network; network propagation ... See more keywords
Protein function prediction using GO similarity-based heterogeneous network propagation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-04933-1
Abstract: Protein function prediction is a fundamental cornerstone in bioinformatics, providing critical insights into biological processes and disease mechanisms. Despite significant advances, challenges persist due to data sparsity and functional ambiguity. We introduce GOHPro (GO Similarity-based… read more here.
Keywords: function; heterogeneous network; prediction; network ... See more keywords
LncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46566
Abstract: Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in diverse cellular processes and biological functions. Exploring the functions associated with lncRNAs may help provide insight into their underlying biological mechanisms. The current… read more here.
Keywords: lncrnas interest; pathways influenced; method; network propagation ... See more keywords
Classifying tumors by supervised network propagation
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty247
Abstract: Motivation Network propagation has been widely used to aggregate and amplify the effects of tumor mutations using knowledge of molecular interaction networks. However, propagating mutations through interactions irrelevant to cancer leads to erosion of pathway… read more here.
Keywords: propagation; tumors supervised; network; supervised network ... See more keywords
Petroleum Refinery Mesh Network Propagation Measurements
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Transactions on Antennas and Propagation"
DOI: 10.1109/tap.2017.2734170
Abstract: This communication presents the results of the first field measurement campaign to characterize the large- and small-scale propagation statistics of the peer-to-peer wireless link in an operating petroleum refinery. Results for ground level transmission and… read more here.
Keywords: propagation; petroleum refinery; network propagation; refinery mesh ... See more keywords
Network Propagation Predicts Drug Synergy in Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0740
Abstract: Combination therapies are commonly used to treat patients with complex diseases that respond poorly to single-agent therapies. In vitro high-throughput drug screening is a standard method for preclinical prioritization of synergistic drug combinations, but it… read more here.
Keywords: synergy; network propagation; drug; drug synergy ... See more keywords
Optimizing network propagation for multi-omics data integration.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS computational biology"
DOI: 10.1371/journal.pcbi.1009161
Abstract: Network propagation refers to a class of algorithms that integrate information from input data across connected nodes in a given network. These algorithms have wide applications in systems biology, protein function prediction, inferring condition-specifically altered… read more here.
Keywords: propagation; multi omics; network; network propagation ... See more keywords