Molecular networking assisted discovery and combinatorial biosynthesis of new antimicrobial pleuromutilins.
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DOI: 10.2139/ssrn.4149497
Abstract: Pleuromutilins, the unique fungal metabolites possessing 5/6/8 tricyclic skeleton, are potent antibacterial leading compounds for the development of new antibiotics. We applied the MS/MS molecular networking technique and the combinatorial biosynthesis approach to discover new… read more here.
Keywords: assisted discovery; biosynthesis; combinatorial biosynthesis; networking assisted ... See more keywords