The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00266
Abstract: CLN1 disease (OMIM #256730) is an early childhood ceroid-lipofuscinosis associated with mutated CLN1, whose product Palmitoyl-Protein Thioesterase 1 (PPT1) is a lysosomal enzyme involved in the removal of palmitate residues from S-acylated proteins. In neurons,… read more here.
Keywords: networks genes; synaptic compartments; axonal synaptic; encoding palmitoylated ... See more keywords
Multi-centre analysis of networks and genes modulated by hypothalamic stimulation in patients with aggressive behaviours.
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.84566
Abstract: Deep brain stimulation targeting the posterior hypothalamus (pHyp-DBS) is being investigated as a treatment for refractory aggressive behaviour, but its mechanisms of action remain elusive. We conducted an integrated imaging analysis of a large multi-centre… read more here.
Keywords: networks genes; multi centre; analysis networks; analysis ... See more keywords