Articles with "networks hydrogen" as a keyword



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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.

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Published in 2018 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.8b06741

Abstract: Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar functionality, a small-molecule approach is often viewed as insufficient to achieve high affinity and specificity. Here we show that small molecules… read more here.

Keywords: hydrogen bonded; proton channel; bound inwardclosed; networks hydrogen ... See more keywords