Rapid and efficient differentiation of functional motor neurons from human iPSC for neural injury modelling.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cell research"
DOI: 10.1016/j.scr.2018.09.006
Abstract: Primary rodent neurons and immortalised cell lines have overwhelmingly been used for in vitro studies of traumatic injury to peripheral and central neurons, but have some limitations of physiological accuracy. Motor neurons (MN) derived from… read more here.
Keywords: rapid efficient; motor neurons; differentiation; neural injury ... See more keywords
Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
Sign Up to like & getrecommendations! Published in 2019 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0324-9
Abstract: The clearance of damaged myelin sheaths is critical to ensure functional recovery from neural injury. Here we show a previously unidentified role for microvessels and their lining endothelial cells in engulfing myelin debris in spinal… read more here.
Keywords: myelin debris; neural injury; macrophage; endothelial cells ... See more keywords
Neural Injury and Repair in a Novel Neonatal Mouse Model of Listeria Monocytogenes Meningoencephalitis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlab079
Abstract: To improve the therapy of neonatal central nervous system infections, well-characterized animal models are urgently needed. The present study analyzes neuropathological alterations with particular focus on neural injury and repair in brains of neonatal mice… read more here.
Keywords: meningitis; injury repair; model; neural injury ... See more keywords
Epigenetic Regulation of Axon Regeneration after Neural Injury
Sign Up to like & getrecommendations! Published in 2017 at "Molecules and Cells"
DOI: 10.14348/molcells.2017.2311
Abstract: When peripheral axons are damaged, neuronal injury signaling pathways induce transcriptional changes that support axon regeneration and consequent functional recovery. The recent development of bioinformatics techniques has allowed for the identification of many of the… read more here.
Keywords: regulation axon; axon regeneration; regeneration; neural injury ... See more keywords
The Effect of Sevoflurane Anesthesia on the Biomarkers of Neural Injury in the Prefrontal Cortex of Aged Marmosets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.918640
Abstract: Background Surgery under general anesthesia leads to neural injury, especially in older patients. Sevoflurane anesthesia without surgery for 2 h does not induce neural injury, however, whether prolonger sevoflurane anesthesia without surgery has the same… read more here.
Keywords: aged marmosets; neural injury; sevoflurane anesthesia; sevoflurane ... See more keywords