Contributions of Single‐Cell Approaches for Probing Heterogeneity and Dynamics of Neural Progenitors Throughout Life: Concise Review
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.3071
Abstract: Development of the forebrain occurs in a stepwise manner from a pool of neural progenitors (NPs), which differs over space and time to produce distinct progenies. The sequence of events leading to the generation of… read more here.
Keywords: single cell; neural progenitors; heterogeneity dynamics; contributions single ... See more keywords
Reference Gene Validation via RT–qPCR for Human iPSC-Derived Neural Stem Cells and Neural Progenitors
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1538-x
Abstract: Correct selection of the reference gene(s) is the most important step in gene expression analysis. The aims of this study were to identify and evaluate the panel of possible reference genes in neural stem cells… read more here.
Keywords: reference; neural progenitors; reference gene; gene ... See more keywords
Spatiotemporal Decline of BMP Signaling Activity in Neural Progenitors Mediates Fate Transition and Safeguards Neurogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.089
Abstract: Neural progenitors undergo temporal fate transition to generate diversified neurons in stereotyped sequence during development. However, the molecular machineries driving progenitor fate change remain unclear. Here, using the cerebellum as a platform, we demonstrate that… read more here.
Keywords: neural progenitors; fate; bmp signaling; fate transition ... See more keywords
Increased Calcium Influx through L-type Calcium Channels in Human and Mouse Neural Progenitors Lacking Fragile X Mental Retardation Protein
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.11.003
Abstract: Summary The absence of FMR1 protein (FMRP) causes fragile X syndrome (FXS) and disturbed FMRP function is implicated in several forms of human psychopathology. We show that intracellular calcium responses to depolarization are augmented in… read more here.
Keywords: neural progenitors; type; calcium; calcium influx ... See more keywords
Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00937-w
Abstract: Alteration of centrosome function and dynamics results in major defects during chromosome segregation and is associated with primary autosomal microcephaly (MCPH). Despite the knowledge accumulated in the last few years, why some centrosomal defects specifically… read more here.
Keywords: asymmetry cell; neural progenitors; plk1; mcph ... See more keywords
Evaluating in vitro neonatal hypoxic-ischemic injury using neural progenitors derived from human embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cells and development"
DOI: 10.1089/scd.2020.0018
Abstract: In hypoxic-ischemic encephalopathy, the Neural Progenitors (NPs) of the developing brain fail to replenish the oligodendrocyte progenitor cells lost during hypoxic-ischemic injury (HII). Here, we aim to examine the influence of HII on the vulnerability… read more here.
Keywords: hypoxic ischemic; neural progenitors; ischemic injury; progenitor ... See more keywords
Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa011
Abstract: De novo microdeletion of chromosome 2p15-16.1 presents clinically recognizable phenotypes that include mental retardation, autism, and microcephaly. Chromosomal maintenance 1 (CRM1) is a gene commonly missing in patients with 2p15-16.1 microdeletion and one of two… read more here.
Keywords: cortical neural; mitosis; autism; apoptosis cortical ... See more keywords
Out of Line or Altered States? Neural Progenitors as a target in a Polygenic Neurodevelopmental Disorder.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental neuroscience"
DOI: 10.1159/000530898
Abstract: The genesis of a mature complement of neurons is thought to require, at least in part, lineages in which neural progenitors have distinct identities recognized by exclusive expression of one or a few molecular markers.… read more here.
Keywords: line altered; target polygenic; neural progenitors; progenitors target ... See more keywords
Genome-wide RNA pol II initiation and pausing in neural progenitors of the rat
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-5829-4
Abstract: BackgroundGlobal RNA sequencing technologies have revealed widespread RNA polymerase II (Pol II) transcription outside of gene promoters. Small 5′-capped RNA sequencing (Start-seq) originally developed for the detection of promoter-proximal Pol II pausing has helped improve… read more here.
Keywords: start; transcription; initiation; rna ... See more keywords
Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1034679
Abstract: Lack of FMR1 protein results in fragile X syndrome (FXS), which is the most common inherited intellectual disability syndrome and serves as an excellent model disease to study molecular mechanisms resulting in neuropsychiatric comorbidities. We… read more here.
Keywords: ipsc derived; ipsc; expression; neural progenitors ... See more keywords