Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24525
Abstract: Background: The retinal pigment epithelium (RPE) is a specialized monolayer of epithelial cells that forms a tight barrier surrounding the neural retina. RPE cells are indispensable for mature photoreceptor renewal and survival, yet how the… read more here.
Keywords: neural retina; expansion; epithelium; retinal pigment ... See more keywords
Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Retinal and Eye Research"
DOI: 10.1016/j.preteyeres.2018.12.002
Abstract: In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing… read more here.
Keywords: neural retina; tissue; blood; immune cells ... See more keywords
Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add4623
Abstract: Lipid nanoparticle (LNP)–based mRNA delivery holds promise for the treatment of inherited retinal degenerations. Currently, LNP-mediated mRNA delivery is restricted to the retinal pigment epithelium (RPE) and Müller glia. LNPs must overcome ocular barriers to… read more here.
Keywords: ller glia; mrna delivery; retina; peptide guided ... See more keywords
Minicircle Delivery to the Neural Retina as a Gene Therapy Approach
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911673
Abstract: Non-viral gene therapy has the potential to overcome several shortcomings in viral vector-based therapeutics. Methods of in vivo plasmid delivery have developed over recent years to increase the efficiency of non-viral gene transfer, yet further… read more here.
Keywords: gene; delivery neural; neural retina; gene therapy ... See more keywords