Characterization of substitutions in the neuraminidase of A(H7N9) influenza viruses selected following serial passage in the presence of different neuraminidase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.05.009
Abstract: Avian A(H7N9) infections in humans have been reported in China since 2013 and are of public health concern due to their severity and pandemic potential. Oseltamivir and peramivir are neuraminidase inhibitors (NAIs) routinely used for… read more here.
Keywords: neuraminidase; presence; river; h7n9 ... See more keywords
Low replicative fitness of neuraminidase inhibitor-resistant H7N9 avian influenza A virus with R292K substitution in neuraminidase in cynomolgus macaques compared with I222T substitution.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104790
Abstract: Human cases of H7N9 influenza A virus infection have been increasing since 2013. The first choice of treatment for influenza is neuraminidase (NA) inhibitors (NAIs), but there is a concern that NAI-resistant viruses are selected… read more here.
Keywords: neuraminidase; h7n9; substitution; virus ... See more keywords
Purification of viral neuraminidase from inclusion bodies produced by recombinant Escherichia coli.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2020.04.005
Abstract: Neuraminidase (NA) is one of the targets for the development of new antivirals against the influenza virus. The recombinant Escherichia coli cells, namely the strains BL21(DE3)pLysS and ArcticExpress(DE3) was used to produce the influenza virus… read more here.
Keywords: recombinant escherichia; neuraminidase; escherichia coli; coli ... See more keywords
Microscale Quantification of the Inhibition of Neuraminidase Using Capillary Nanogel Electrophoresis.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03584
Abstract: Neuraminidase inhibitors modulate infections that involve sialic acids, making quantitative analyses of this inhibitory effect important for selecting and designing potential therapeutics. An automated nanogel capillary electrophoresis system is developed that integrates a 5 nL… read more here.
Keywords: inhibition; capillary nanogel; microscale quantification; neuraminidase ... See more keywords
Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes
Sign Up to like & getrecommendations! Published in 2017 at "Nature microbiology"
DOI: 10.1038/s41564-017-0011-8
Abstract: A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant receptor binding protein, haemagglutinin. While… read more here.
Keywords: neuraminidase; murine; monoclonal antibodies; neuraminidase epitopes ... See more keywords
Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12101-3
Abstract: Influenza is an annual seasonal epidemic that has continually drawn public attentions, due to the potential death toll and drug resistance. Neuraminidase, which is essential for the spread of influenza virus, has been regarded as… read more here.
Keywords: neuraminidase; i222r mutant; dual h274y; h274y i222r ... See more keywords
Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010343
Abstract: Oseltamivir is a widely used influenza virus neuraminidase (NA) inhibitor that prevents the release of new virus particles from host cells. However, oseltamivir-resistant strains have emerged, but effective drugs against them have not yet been… read more here.
Keywords: oseltamivir; design new; mechanism oseltamivir; binding mechanism ... See more keywords
Anti-neuraminidase and anti-hemagglutinin immune serum can confer inter-lineage cross protection against recent influenza B
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280825
Abstract: Influenza B viruses (IBV) are responsible for a considerable part of the burden caused by influenza virus infections. Since their emergence in the 1980s, the Yamagata and Victoria antigenic lineages of influenza B circulate in… read more here.
Keywords: protection; lineage cross; influenza; inter lineage ... See more keywords
Study on The Interaction Between Silibinin and Neuraminidase.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical design"
DOI: 10.2174/1381612829666230515165041
Abstract: BACKGROUND Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity. OBJECTIVE This study aims to explore the interaction between silibinin and… read more here.
Keywords: silibinin neuraminidase; activity; neuraminidase; interaction silibinin ... See more keywords
DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Journal"
DOI: 10.2210/pdb6g01/pdb
Abstract: Influenza neuraminidase is responsible for the escape of new viral particles from the infected cell surface. Several neuraminidase inhibitors are used clinically to treat patients or stockpiled for emergencies. However, the increasing development of viral… read more here.
Keywords: neuraminidase; inhibitor; antibody; method ... See more keywords
Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.945229
Abstract: Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses. This process has been extensively reported in peripheral immune cells and also, although modestly,… read more here.
Keywords: brain; immune priming; neuraminidase; immune ... See more keywords