Microwave-assisted synthesis, characterization and bioassay of acylhydrazone derivatives as influenza neuraminidase inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2015-6
Abstract: A series of acylhydrazone derivatives (4a–4s) were synthesized via microwave irradiation with short reaction time and good yields. The crystal structure of compound 4j was further determined by single-crystal X-ray diffraction. All of the derivatives… read more here.
Keywords: microwave assisted; assisted synthesis; neuraminidase inhibitors; influenza neuraminidase ... See more keywords
Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016–2017
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.07.001
Abstract: A total of 13672 viruses, collected by World Health Organization recognised National Influenza Centres between May 2016 and May 2017, were assessed for neuraminidase inhibitor susceptibility by four WHO Collaborating Centres for Reference and Research… read more here.
Keywords: susceptibility; global update; influenza; neuraminidase inhibitor ... See more keywords
Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018-2020.
Sign Up to like & getrecommendations! Published in 2022 at "Antiviral research"
DOI: 10.1016/j.antiviral.2022.105281
Abstract: Global analysis of the susceptibility of influenza viruses to neuraminidase (NA) inhibitors (NAIs) and the polymerase acidic (PA) inhibitor (PAI) baloxavir was conducted by five World Health Organization Collaborating Centres for Reference and Research on… read more here.
Keywords: neuraminidase inhibitors; viruses neuraminidase; susceptibility; inhibitor ... See more keywords
2D-SAR, Topomer CoMFA and molecular docking studies on avian influenza neuraminidase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2018.11.007
Abstract: Avian influenza is a serious zoonotic infectious disease with huge negative impacts on local poultry farming, human health and social stability. Therefore, the design of new compounds against avian influenza has been the focus in… read more here.
Keywords: avian influenza; molecular docking; topomer comfa; neuraminidase inhibitors ... See more keywords
Discovery of C-1 modified oseltamivir derivatives as potent influenza neuraminidase inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.01.050
Abstract: Inspired by our initial discovery about a series of neuraminidase (NA) inhibitors targeting the 150-cavity, in present study, we designed, synthesized, and biologically tested a panel of novel oseltamivir derivatives with C-1 modification, targeting the… read more here.
Keywords: oseltamivir derivatives; modified oseltamivir; group; discovery modified ... See more keywords
Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111635
Abstract: The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing… read more here.
Keywords: design synthesis; oseltamivir derivatives; substituted oseltamivir; novel substituted ... See more keywords
An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicerae Japonicae.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.07.006
Abstract: Flos Lonicerae Japonicae(Jinyinhua) possesses clearing heat and detoxification activity, and has been used as a traditional Chinese medicine to treat influenza for many years. Due to the complex chemical composition and diverse content of Jinyinhua,… read more here.
Keywords: minor neuraminidase; characterization; esi tof; neuraminidase inhibitors ... See more keywords
Assessment of adverse events related to anti-influenza neuraminidase inhibitors using the FDA adverse event reporting system and online patient reviews
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DOI: 10.1038/s41598-020-60068-5
Abstract: The recommended antiviral drugs available for the treatment and prevention of influenza are neuraminidase inhibitors (NAIs). The aim of this study was to evaluate age-related clinical manifestations of adverse events (AEs) related to NAIs. FAERS… read more here.
Keywords: reporting; adverse events; assessment adverse; influenza neuraminidase ... See more keywords
Recent progress in chemical approaches for the development of novel neuraminidase inhibitors
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DOI: 10.1039/d0ra07283d
Abstract: Influenza virus is the main cause of an infectious disease called influenza affecting the respiratory system including the throat, nose and lungs. Neuraminidase inhibitors are reagents used to block the enzyme called neuraminidase to prevent… read more here.
Keywords: influenza; progress chemical; neuraminidase inhibitors; recent progress ... See more keywords
Neuraminidase Inhibitors from the Fruiting Body of Glaziella splendens
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DOI: 10.1080/12298093.2019.1616377
Abstract: Abstract Neuraminidase (NA) cleaves the glycosidic bond linkages of sialic acids to release the mature virions from infected cells and has been an attractive therapeutic target for anti-influenza agents. In our ongoing investigation of NA… read more here.
Keywords: body glaziella; fruiting body; inhibitors fruiting; glaziella splendens ... See more keywords
Influenza A virus hemagglutinin mutations associated with use of neuraminidase inhibitors correlate with decreased inhibition by anti-influenza antibodies
Sign Up to like & getrecommendations! Published in 2019 at "Virology Journal"
DOI: 10.1186/s12985-019-1258-x
Abstract: BackgroundVaccination and the use of neuraminidase inhibitors (NAIs) are currently the front lines of defense against seasonal influenza. The activity of influenza vaccines and antivirals drugs such as the NAIs can be affected by mutations… read more here.
Keywords: anti influenza; influenza; use neuraminidase; neuraminidase inhibitors ... See more keywords