Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.03.032
Abstract: AMPA- and NMDA-type glutamate receptors mediate distinct postsynaptic signals that differ characteristically among synapses. How postsynaptic AMPA- and NMDA-receptor levels are regulated, however, remains unclear. Using newly generated conditional knockin mice that enable genetic control… read more here.
Keywords: neurexin; ampa receptor; nmda ampa; receptor ... See more keywords
Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2300363120
Abstract: Significance Previous in vivo studies showed that neurexin-2 unexpectedly regulates synaptic connectivity in hippocampal circuits not by inducing, but by repressing excitatory synapses. The present study demonstrates that as assessed by heterologous synapse formation experiments,… read more here.
Keywords: alternative splicing; release probability; neurexin; mechanism ... See more keywords
Loss of neurexin-1 in Drosophila melanogaster results in altered energy metabolism and increased seizure susceptibility
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac115
Abstract: Abstract Although autism is typically characterized by differences in language, social interaction and restrictive, repetitive behaviors, it is becoming more well known in the field that alterations in energy metabolism and mitochondrial function are comorbid… read more here.
Keywords: metabolism; energy metabolism; neurexin; nrx null ... See more keywords
Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010016
Abstract: The functional properties of neural circuits are defined by the patterns of synaptic connections between their partnering neurons, but the mechanisms that stabilize circuit connectivity are poorly understood. We systemically examined this question at synapses… read more here.
Keywords: mediated axonal; dendritic spines; delivery presynaptic; neurexin ... See more keywords
Mild Amnestic Cognitive Impairment and Depressive Symptoms in Autoimmune Encephalitis Associated with Serum Anti-Neurexin-3α Autoantibodies
Sign Up to like & getrecommendations! Published in 2021 at "Brain Sciences"
DOI: 10.3390/brainsci11060673
Abstract: (1) Background: autoimmune encephalitis associated with neurexin-3α antibodies is a seldom reported disease entity often accompanied by a severe clinical neuropsychiatric syndrome. (2) Method: we report on the case of a 58-year-old man diagnosed with… read more here.
Keywords: autoimmune encephalitis; neurexin; encephalitis associated; serum ... See more keywords