The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.06.009
Abstract: Cerebrovascular pathology is common in aging and Alzheimer's disease (AD). The microvasculature is particularly vulnerable, with capillary-level microhemorrhages coinciding with amyloid beta deposits in senile plaques. In the current analysis, we assessed the relationship between… read more here.
Keywords: alzheimer disease; neuritic plaque; plaque alzheimer; disease ... See more keywords
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-018-0244-x
Abstract: BackgroundBesides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD). Microglia are believed to be key… read more here.
Keywords: intraneuronal amyloid; csf1r; neuritic plaque; deposition ... See more keywords