Development of a skin- and neuro-attenuated live vaccine for varicella
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28329-1
Abstract: Varicella caused by the primary infection of varicella-zoster virus (VZV) exerts a considerable disease burden globally. Current varicella vaccines consisting of the live-attenuated vOka strain of VZV are generally safe and effective. However, vOka retains… read more here.
Keywords: attenuated live; varicella; neuro attenuated; development skin ... See more keywords
Rational Design of a Skin- and Neuro-Attenuated Live Varicella Vaccine: A Review and Future Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14050848
Abstract: Primary varicella-zoster virus (VZV) infection causes varicella, which remains a prominent public health concern in children. Current varicella vaccines adopt the live-attenuated Oka strain, vOka, which retains the ability to infect neurons, establish latency and… read more here.
Keywords: skin neuro; neuro attenuated; varicella vaccine; vaccine ... See more keywords
Efficacy of an HSV-1 Neuro-Attenuated Vaccine in Mice Is Reduced by Preventing Viral DNA Replication
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14050869
Abstract: We previously isolated an HSV-1 mutant, KOS-NA, that contains two non-synonymous mutations in UL39. One of the mutations, resulting in an R950H amino acid substitution in ICP6, renders KOS-NA severely neuro-attenuated and significantly reduces HSV-1… read more here.
Keywords: neuro attenuated; viral dna; hsv; mice ... See more keywords