Chemical synthesis of 7α-hydroxypregnenolone, a neuroactive steroid that stimulates locomotor activity
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DOI: 10.1016/j.steroids.2017.10.004
Abstract: Graphical abstract Figure. No Caption available. HighlightsTwo convenient approaches for the synthesis of 7&agr;‐hydroxypregnenolone are reported.Explanation of the stereoselectivity of reduction at C7‐ketone.Potential application to other steroid analogs oxygenated at C7. Abstract 7&agr;‐Hydroxypregnenolone is an… read more here.
Keywords: neuroactive steroid; steroid stimulates; stimulates locomotor; locomotor activity ... See more keywords
Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain
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DOI: 10.1111/bph.14930
Abstract: Neuroactive steroid (3β,5β,17β)‐3‐hydroxyandrostane‐17‐carbonitrile (3β‐OH) is a novel hypnotic and voltage‐dependent blocker of T‐type calcium channels. Here, we examine its potential analgesic effects and adjuvant anaesthetic properties using a post‐surgical pain model in rodents. read more here.
Keywords: neuroactive steroid; post surgical; type calcium; surgical pain ... See more keywords
Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats
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DOI: 10.1111/jne.12916
Abstract: Acute swim stress results in the robust production of several neuroactive steroids, which act as mediators of the stress response. These steroids include glucocorticoids, and positive GABAA receptor modulatory steroids such as allopregnanolone and tetrahydrocorticosterone… read more here.
Keywords: neuroactive steroid; pns offspring; acute stress; stress ... See more keywords
Pharmacological Characterization of a Novel Neuroactive Steroid Prodrug, NTS-104, and Its Neuroprotective Activity in Experimental Stroke Models
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DOI: 10.1161/strokeaha.122.038507
Abstract: Background: Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-105,… read more here.
Keywords: nts 104; neuroactive steroid; prodrug nts; nts 105 ... See more keywords