Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains.
Sign Up to like & getrecommendations! Published in 2017 at "Alcohol"
DOI: 10.1016/j.alcohol.2016.07.011
Abstract: Neuroactive steroids modulate alcohol's impact on brain function and behavior. Ethanol exposure alters neuroactive steroid levels in rats, humans, and some mouse strains. We conducted an exploratory analysis of the neuroactive steroids (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP), (3α,5α)-3,21-dihydroxypregnan-20-one… read more here.
Keywords: neuroactive steroids; variation; thp; mouse strains ... See more keywords
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00846
Abstract: Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series of 5β-nor-19-pregnan-20-one analogues bearing substituted pyrazoles and triazoles at… read more here.
Keywords: neuroactive steroids; pregnan one; hydroxy methyl; methyl cyano ... See more keywords
Aging is associated with lower neuroactive steroids and worsened outcomes following cerebral ischemia in male mice.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac183
Abstract: Ischemic stroke is a leading cause of disability and death and aging is the main non-modifiable risk factor. Following ischemia, neuroactive steroids have been shown to play a key role in cerebroprotection. Thus, brain steroid… read more here.
Keywords: young mice; neuroactive steroids; brain; cerebral ischemia ... See more keywords
The influence of neuroactive steroids on cortical evoked response potentials and attentive performance of cognitive tasks in young adults – A cross-sectional study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neurosciences in Rural Practice"
DOI: 10.25259/jnrp_267_2024
Abstract: The term “neurosteroids” is now often employed to describe steroids such as dehydroepiandrostenedione-sulfate (DHEA-S) that is produced inside the hippocampus and other brain regions. The name was then revised to neuroactive steroids (NASs), which are… read more here.
Keywords: cortical evoked; influence; response; neuroactive steroids ... See more keywords
Neuroactive steroids in the programming of neurodevelopment: implications of maternal obesity
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2025.1703103
Abstract: Neuroactive steroids synthesized within the maternal-placental-fetal unit play a crucial role in fetal neurodevelopment by regulating cell proliferation, migration, and myelination, neurogenesis, gliogenesis, and synaptogenesis, ultimately shaping brain maturation. Dysregulation of neuroactive steroid metabolism, receptor… read more here.
Keywords: neuroactive steroid; obesity; programming neurodevelopment; obesity neuroactive ... See more keywords
Preventing Phosphorylation of the GABAAR β3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.817996
Abstract: Neuroactive steroids (NASs) have potent anxiolytic, anticonvulsant, sedative, and hypnotic actions, that reflect in part their efficacy as GABAAR positive allosteric modulators (PAM). In addition to this, NAS exert metabotropic effects on GABAergic inhibition via… read more here.
Keywords: neuroactive steroids; preventing phosphorylation; gabaar subunit; subunit ... See more keywords
Analytical Methods for the Determination of Neuroactive Steroids
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11040553
Abstract: Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions. Their biosynthesis occurs directly in the nervous system (so-called neurosteroids) or in peripheral… read more here.
Keywords: neuroactive steroids; methods determination; analytical methods; determination neuroactive ... See more keywords
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11071026
Abstract: Evidence from clinical and preclinical studies implicates dysfunction of N-methyl-D-aspartate receptors (NMDARs) in schizophrenia progression and symptoms. We investigated the antipsychotic effect of two neuroactive steroids in an animal model of schizophrenia induced by systemic… read more here.
Keywords: neuroactive steroids; modulation; animal model; nmda receptor ... See more keywords
Physiopathological Role of Neuroactive Steroids in the Peripheral Nervous System
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21239000
Abstract: Peripheral neuropathy (PN) refers to many conditions involving damage to the peripheral nervous system (PNS). Usually, PN causes weakness, numbness and pain and is the result of traumatic injuries, infections, metabolic problems, inherited causes, or… read more here.
Keywords: neuroactive steroids; nervous system; peripheral nervous; physiopathological role ... See more keywords
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113075
Abstract: Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid… read more here.
Keywords: neuroactive steroids; neurosteroids neuroactive; muscarinic receptors; modulation muscarinic ... See more keywords
Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders
Sign Up to like & getrecommendations! Published in 2024 at "Life"
DOI: 10.3390/life14050582
Abstract: Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors. Clinical studies highlight their therapeutic potential, particularly in conditions… read more here.
Keywords: neuropsychiatric disorders; steroids toll; toll like; neuroactive steroids ... See more keywords