SLC34A2 promotes neuroblastoma cell stemness via enhancement of miR‐25/Gsk3β‐mediated activation of Wnt/β‐catenin signaling
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12594
Abstract: Cancer stem cells contribute to cancer progression, but the mechanisms underlying neuroblastoma stem cell development are unclear. Here, we examined the roles of the transcription factor SLC34A2 in regulating the stemness of neuroblastoma cells. We… read more here.
Keywords: stemness; mir gsk3; neuroblastoma cell; neuroblastoma cells ... See more keywords
Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y
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DOI: 10.1007/s00044-018-2241-6
Abstract: Four new glyco-conjugated tacrine derivatives, 4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (1), 4-(2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl)-1-(1,2,3,4-tetrahydroacridin-9-yl)thiosemicarbazide (2), 2′-(1,2,3,4-tetrahydroacridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-1′,3′-thiazolidin-4′-one (3) and [2′-(1,2,3,4-tetrahydro-acridin-9-yl)hydrazono-3′-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4′-oxothiazolidin-5-yliden]acetate (4) were synthesized and their characteristics were investigated. All of the novel derivatives were found to inhibit acetylcholinesterase obtained from Electrophorus electricus… read more here.
Keywords: human neuroblastoma; tetra acetyl; cytotoxicity; neuroblastoma cells ... See more keywords
Expression of DHA-Metabolizing Enzyme Alox15 is Regulated by Selective Histone Acetylation in Neuroblastoma Cells
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DOI: 10.1007/s11064-017-2448-9
Abstract: The omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) is enriched in neural membranes of the CNS, and recent studies have shown a role of DHA metabolism by 15-lipoxygenase-1 (Alox15) in prefrontal cortex resolvin D1 formation,… read more here.
Keywords: dha; expression; histone; alox15 ... See more keywords
The Neuroprotective Role of the GM1 Oligosaccharide, II3Neu5Ac-Gg4, in Neuroblastoma Cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1556-8
Abstract: Recently, we demonstrated that the GM1 oligosaccharide, II3Neu5Ac-Gg4 (OligoGM1), administered to cultured murine Neuro2a neuroblastoma cells interacts with the NGF receptor TrkA, leading to the activation of the ERK1/2 downstream pathway and to cell differentiation.… read more here.
Keywords: ii3neu5ac gg4; gm1; gm1 oligosaccharide; oligosaccharide ii3neu5ac ... See more keywords
Methylmercury exposure alters RNA splicing in human neuroblastoma SK-N-SH cells: Implications from proteomic and post-transcriptional responses.
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DOI: 10.1016/j.envpol.2018.03.019
Abstract: The neurotoxic effects of methylmercury (MeHg) have been intensively studied. However, the molecular mechanisms responsible for the neurotoxicity of MeHg are not fully understood. To decipher these mechanisms, proteomic and high-throughput mRNA sequencing (RNA-seq) technique… read more here.
Keywords: exposure; human neuroblastoma; mehg exposure; rna splicing ... See more keywords
Geniposide ameliorated fluoxetine‐suppressed neurite outgrowth in Neuro2a neuroblastoma cells
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DOI: 10.1016/j.lfs.2019.04.003
Abstract: Aim: Fluoxetine (FXT), a selective serotonin reuptake inhibitor (SSRI), is one of the most common psychiatric medications clinically prescribed; while over‐produced serotonin may suppress neurite development. The role of major iridoids like geniposide (GPS) and… read more here.
Keywords: outgrowth; outgrowth neuro2a; neurite outgrowth; neuro2a neuroblastoma ... See more keywords
Methamphetamine regulates βAPP processing in human neuroblastoma cells
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DOI: 10.1016/j.neulet.2019.02.023
Abstract: Methamphetamine is a potent and highly addictive psychostimulant whose abuse has turned out to be a global health hazard. The multitudinous effects it exerts at the cellular level induces neurotoxic responses in the human brain,… read more here.
Keywords: methamphetamine regulates; app processing; regulates app; human neuroblastoma ... See more keywords
Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation
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DOI: 10.1016/j.redox.2018.10.003
Abstract: Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to… read more here.
Keywords: protein; mao levels; mao; monoamine ... See more keywords
Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells.
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DOI: 10.1016/j.tox.2019.03.009
Abstract: Although ellipticine (Elli) is an efficient anticancer agent, it exerts several adverse effects. One approach to decrease the adverse effects of drugs is their encapsulation inside a suitable nanocarrier, allowing targeted delivery to tumour tissue… read more here.
Keywords: neuroblastoma; cells ellipticine; cytochrome p450; ellipticine ... See more keywords
Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer’s disease
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DOI: 10.1038/cddiscovery.2017.7
Abstract: Malathion is an organophosphate with severe neurotoxic effects. Upon acute exposure, malathion initially enhances cholinergic activity by inhibition of acetylcholinesterase, which is its major pathological mechanism. Malathion also induces non-cholinergic neuronal cell death in neurodegenerative… read more here.
Keywords: cell death; malathion; n2a cells; cell ... See more keywords
CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells
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DOI: 10.1038/s41598-017-10311-3
Abstract: Emerging evidence has shown that dioxin causes dysregulation of microRNAs (miRs) in a variety of tissues or cells. However, little is known about dioxin effects on neuronal miRs expression. In the present study, 277 differentially… read more here.
Keywords: cdc42; dioxin; hsa mir; mir 608 ... See more keywords