Association of Regional White Matter Hyperintensities With Longitudinal Alzheimer-Like Pattern of Neurodegeneration in Older Adults
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.25166
Abstract: Key Points Question What is the association of small vessel cerebrovascular disease, operationalized as white matter hyperintensities (WMH), with cortical thinning in a racially and ethnically diverse population of older adults? Findings In this cohort… read more here.
Keywords: cortical thinning; neurodegeneration; older adults; matter hyperintensities ... See more keywords
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2020.4986
Abstract: Key Points Question What is the potential of blood-based biomarkers for predicting and monitoring the progression of Alzheimer disease neurodegeneration? Findings In this cohort study that included 1113 participants from the multicentric Alzheimer’s Disease Neuroimaging… read more here.
Keywords: neurofilament light; alzheimer disease; disease; neurodegeneration ... See more keywords
Lysosomal peptidases—intriguing roles in cancer progression and neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13372
Abstract: Lysosomal peptidases are hydrolytic enzymes capable of digesting waste proteins that are targeted to lysosomes via endocytosis and autophagy. Besides intracellular protein catabolism, they play more specific roles in several other cellular processes and pathologies,… read more here.
Keywords: intriguing roles; progression; neurodegeneration; peptidases intriguing ... See more keywords
Thalamic atrophy in multiple sclerosis: A magnetic resonance imaging marker of neurodegeneration throughout disease
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25150
Abstract: Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based marker associated with neurodegeneration to hasten development of neuroprotective treatments. Our objective is to describe the longitudinal evolution of thalamic atrophy in MS and normal aging,… read more here.
Keywords: resonance imaging; magnetic resonance; neurodegeneration; marker ... See more keywords
Imaging gradual neurodegeneration in a basal ganglia model disease
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25566
Abstract: X‐linked dystonia‐parkinsonism (XDP) is a neurodegenerative disease with adult onset dystonia and subsequent parkinsonism. Postmortem and imaging studies revealed remarkable striatal pathology, with a predominant involvement of the striosomal compartment in the early phase. Here,… read more here.
Keywords: imaging gradual; gradual neurodegeneration; neurodegeneration basal; disease ... See more keywords
Neurodegeneration in type 2 diabetes: Alzheimer's as a case study
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1577
Abstract: Rigorous research in the last few years has shown that in addition to the classical mechanism of neurodegeneration, certain unconventional mechanisms may also lead to neurodegenerative disease. One of them is a widely studied metabolic… read more here.
Keywords: neurodegeneration; type diabetes; neurodegeneration type; case study ... See more keywords
Neurodegeneration in a novel invertebrate model system: Failed microtubule‐mediated cell adhesion and unraveling of macroglia
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25450
Abstract: Neurodegenerative diseases are among the main causes of death in the United States, leading to irreversible disintegration of neurons. Despite intense international research efforts, cellular mechanisms that initiate neurodegeneration remain elusive, thus inhibiting the development… read more here.
Keywords: model system; neurodegeneration; model; invertebrate ... See more keywords
Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23806
Abstract: Neurodegeneration is associated with inflammation and mismanaged iron homeostasis, leading to increased concentration of non‐transferrin‐bound iron (NTBI) in the brain. NTBI can be taken up by cells expressing Zrt‐, Irt‐like protein‐14 (ZIP14), which is regulated… read more here.
Keywords: neurodegeneration; iron overload; expression; zip14 ... See more keywords
Altered basal forebrain BOLD signal variability at rest in posttraumatic stress disorder: A potential candidate vulnerability mechanism for neurodegeneration in PTSD
Sign Up to like & getrecommendations! Published in 2021 at "Human Brain Mapping"
DOI: 10.1002/hbm.25454
Abstract: Individuals with posttraumatic stress disorder (PTSD) are at increased risk for the development of various forms of dementia. Nevertheless, the neuropathological link between PTSD and neurodegeneration remains unclear. Degeneration of the human basal forebrain constitutes… read more here.
Keywords: seed; neurodegeneration; bold signal; basal forebrain ... See more keywords
Visual impairment and retinal and brain neurodegeneration: A population‐based study
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26237
Abstract: Visual impairment and retinal neurodegeneration are intrinsically connected and both have been associated with cognitive impairment and brain atrophy, but the underlying mechanisms remain unclear. To investigate whether transneuronal degeneration is implicated, we systematically assessed… read more here.
Keywords: retinal neurodegeneration; brain; neurodegeneration; impairment retinal ... See more keywords
The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Movement Disorders"
DOI: 10.1002/mds.27718
Abstract: We recently demonstrated that NLY01, a novel glucagon‐like peptide‐1 receptor agonist, exerts neuroprotective effects in two mouse models of PD in a glia‐dependent manner. NLY01 prevented microglia from releasing inflammatory mediators known to convert astrocytes… read more here.
Keywords: avenues pharmacological; paradigm new; new avenues; neurodegeneration ... See more keywords