ATP binds and inhibits the neurodegeneration-associated fibrillization of the FUS RRM domain
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DOI: 10.1038/s42003-019-0463-x
Abstract: Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the disordered domain of FUS containing the RG/RGG sequence… read more here.
Keywords: neurodegeneration associated; fus; rrm domain; fibrillization ... See more keywords