Signaling by cGAS–STING in Neurodegeneration, Neuroinflammation, and Aging
Sign Up to like & getrecommendations! Published in 2021 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2020.10.008
Abstract: Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is relayed via the cGAS-STING pathway: this… read more here.
Keywords: neurodegeneration neuroinflammation; cgas sting; cgas; signaling cgas ... See more keywords
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118819119
Abstract: Significance It is increasingly recognized that chronic neuroinflammation is causally relevant to neurodegeneration. In Parkinson’s disease (PD), α-synuclein pathology activates inflammatory signaling that disturbs parenchymal homeostasis and disrupts neuron-glia interactions. Herein, we report that the… read more here.
Keywords: sting mediates; neuroinflammation nigrostriatal; neuroinflammation; nigrostriatal synucleinopathy ... See more keywords
Cerebrospinal Fluid Proteomics in Friedreich Ataxia Reveals Markers of Neurodegeneration and Neuroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.885313
Abstract: Clinical trials in rare diseases as Friedreich ataxia (FRDA) offer special challenges, particularly when multiple treatments become ready for clinical testing. Regulatory health authorities have developed specific pathways for “orphan” drugs allowing the use of… read more here.
Keywords: frda patients; cerebrospinal fluid; friedreich ataxia; neurodegeneration neuroinflammation ... See more keywords