Glycosphingolipids within membrane contact sites influence their function as signaling hubs in neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13605
Abstract: Intracellular organelles carry out many of their functions by engaging in extensive inter-organellar communication through specialized membrane contact sites (MCSs) formed where two organelles tether to each other or to the plasma membrane without fusing.… read more here.
Keywords: contact sites; membrane contact; signaling hubs; membrane ... See more keywords
Dysregulation of 14‐3‐3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.421
Abstract: The highly conserved 14‐3‐3 proteins interact with key players involved in Parkinson's disease (PD) and other neurodegenerative disorders. We recently demonstrated that 14‐3‐3 phosphorylation is increased in PD models and that increased 14‐3‐3 phosphorylation reduces… read more here.
Keywords: diseases lewy; dysregulation proteins; neurodegenerative diseases; pathology ... See more keywords
Fluorescent Diagnostic Probes in Neurodegenerative Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202001945
Abstract: Neurodegenerative diseases are debilitating disorders that feature progressive and selective loss of function or structure of anatomically or physiologically associated neuronal systems. Both chronic and acute neurodegenerative diseases are associated with high morbidity and mortality… read more here.
Keywords: neurodegenerative disease; neurodegenerative diseases; fluorescent diagnostic; probes neurodegenerative ... See more keywords
HuR promotes the molecular signature and phenotype of activated microglia: Implications for amyotrophic lateral sclerosis and other neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23137
Abstract: In neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), chronic activation of microglia contributes to disease progression. Activated microglia produce cytokines, chemokines, and other factors that normally serve to clear infection or damaged tissue either… read more here.
Keywords: phenotype; hur; neurodegenerative diseases; amyotrophic lateral ... See more keywords
Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23693
Abstract: Astrocytes are the most widespread and heterogeneous glial cells in the central nervous system and key regulators for brain development. They are capable of receiving neurotransmitters produced by synaptic activities and regulating synaptic functions by… read more here.
Keywords: therapeutic strategy; neurodegenerative diseases; potential therapeutic; optogenetic manipulation ... See more keywords
Central nervous system organoids for modeling neurodegenerative diseases
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DOI: 10.1002/iub.2595
Abstract: Recent advances in induced pluripotent stem cell (iPSC) technology have allowed researchers to generate neurodegenerative disease‐specific iPSCs and use the cells to derive a variety of relevant cell populations for laboratory modeling and drug testing.… read more here.
Keywords: cell; central nervous; organoids modeling; cns organoids ... See more keywords
New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28361
Abstract: Neurodegenerative diseases (NDs) are a diversity of neurological disorders characterized by the progressive degeneration of the structure and function of the central nervous system (CNS). The most common NDs are Alzheimer's disease (AD), Parkinson's disease… read more here.
Keywords: long noncoding; insights role; common nds; neurodegenerative diseases ... See more keywords
Apelin/APJ system: A novel promising target for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29001
Abstract: Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are incurable diseases characterized by progressive loss of cognitive or motor function, which construct a serious threat to the life quality of… read more here.
Keywords: apelin apj; apelin; apj system; target ... See more keywords
COVID‐19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29937
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the agent of novel coronavirus 2019 (COVID‐19), has kept the globe in disquiets due to its severe life‐threatening conditions. The most common symptoms of COVID‐19… read more here.
Keywords: covid olfactory; olfactory dysfunction; neurodegenerative diseases; possible associative ... See more keywords
CRISPR/Cas9‐Based Functional Genomics in Human Induced Pluripotent Stem Cell–Derived Models: Can “the Stars Align” for Neurodegenerative Diseases?
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28998
Abstract: In science there are times when the concurrent development of new tools, availability of relevant models, and accessibility to large data sets can coalesce to yield unanticipated conceptual advances. Today, data from genetic studies powered… read more here.
Keywords: crispr cas9; cell; disease; gwas ... See more keywords
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21965
Abstract: The blood platelet plays an important role but often remains under-recognized in several vascular complications and associated diseases. Surprisingly, platelet hyperactivity and hyperaggregability have often been considered the critical risk factors for developing vascular dysfunctions… read more here.
Keywords: options management; drugs potential; therapeutic options; potential therapeutic ... See more keywords