Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201703458
Abstract: Transition-metal dyshomeostasis is recognized as a critical pathogenic factor at the onset and progression of neurodegenerative disorder (ND). Excess transition-metal ions such as Cu2+ can catalyze the generation of cytotoxic reactive oxygen species and thereafter… read more here.
Keywords: nanosheets neuroprotective; phosphorus nanosheets; neurodegenerative disorder; black phosphorus ... See more keywords
Is pseudoexfoliation glaucoma a neurodegenerative disorder?
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biosciences"
DOI: 10.1007/s12038-021-00217-8
Abstract: Pseudoexfoliation (PEX) is a systemic age-related progressive disorder with ocular manifestations. The earlier stage of the disease, pseudoexfoliation syndrome (PEXS) involves deposition of white fibrillar aggregates on anterior and posterior eye tissues. It is also… read more here.
Keywords: pex; disorder; neurodegenerative disorder; pseudoexfoliation glaucoma ... See more keywords
PARS2 and NARS2 mutations in infantile-onset neurodegenerative disorder
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DOI: 10.1038/jhg.2016.163
Abstract: Here we present four unrelated families with six individuals that have infantile-onset developmental delay/regression and epilepsy. Whole-exome sequencing revealed compound heterozygous mutations, c.[283G>A];[607G>A] in a gene encoding prolyl-tRNA synthetase (PARS2) in one family. Two pairs… read more here.
Keywords: nars2 mutations; infantile onset; neurodegenerative disorder; pars2 nars2 ... See more keywords
Neurodegenerative Disorder Risk in Krabbe Disease Carriers
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DOI: 10.3390/ijms232113537
Abstract: Krabbe disease (KD) is a rare autosomal recessive disorder caused by mutations in the galactocerebrosidase gene (GALC). Defective GALC causes aberrant metabolism of galactolipids present almost exclusively in myelin, with consequent demyelinization and neurodegeneration of… read more here.
Keywords: disease; neurodegenerative disorder; krabbe disease; disorder risk ... See more keywords