Handgrip strength asymmetry is associated with the risk of neurodegenerative disorders among Chinese older adults.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cachexia, sarcopenia and muscle"
DOI: 10.1002/jcsm.12933
Abstract: BACKGROUND Neurodegenerative disorders, as the irreversible condition, have a long, silent preclinical period. Recognition of early physical signs of neurodegenerative disorders had important practical implications for identifying at-risk population. The aim of this study was… read more here.
Keywords: risk; neurodegenerative disorders; handgrip strength; asymmetry ... See more keywords
Application of Neuromelanin MR Imaging in Parkinson Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.28414
Abstract: MRI has been used to develop biomarkers for movement disorders such as Parkinson disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive supranuclear palsy and multiple system atrophy. One of these imaging biomarkers… read more here.
Keywords: application neuromelanin; iron; parkinson disease; neuromelanin imaging ... See more keywords
Cyclic dipeptide‐based small molecules modulate zinc‐mediated liquid–liquid phase separation of tau
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Peptide Science"
DOI: 10.1002/psc.3465
Abstract: Liquid–liquid phase separation (LLPS) is a complex physicochemical phenomenon mediated by multivalent transient weak interactions among macromolecules like polymers, proteins, and nucleic acids. It has implications in cellular physiology and disease conditions like cancer and… read more here.
Keywords: liquid phase; phase separation; liquid liquid; liquid ... See more keywords
Where do we stand now regarding treatment of psychiatric and neurodegenerative disorders? Considerations in using magnetoelectric nanoparticles as an innovative approach.
Sign Up to like & getrecommendations! Published in 2022 at "Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology"
DOI: 10.1002/wnan.1781
Abstract: Almost 1000 million people have recently been diagnosed with a mental health or substance disorder (Ritchie & Roser, 2018). Psychiatric disorders, and their treatment, represent a big burden to the society worldwide, causing about 8 million… read more here.
Keywords: magnetoelectric nanoparticles; stand regarding; treatment psychiatric; regarding treatment ... See more keywords
Let’s make microglia great again in neurodegenerative disorders
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-017-1792-x
Abstract: All of the common neurodegenerative disorders—Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and prion diseases—are characterized by accumulation of misfolded proteins that trigger activation of microglia; brain-resident mononuclear phagocytes. This chronic form of neuroinflammation is… read more here.
Keywords: microglia great; make microglia; neurodegenerative disorders; disease ... See more keywords
Neuroinflammation in Neurodegenerative Disorders—a Review
Sign Up to like & getrecommendations! Published in 2017 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-017-0733-2
Abstract: The potential for positron emission tomography (PET) to detect neuroinflammation in vivo has sparked a remarkable interest in various disciplines of neuroscience. Early PET radioligands, such as [11C]PK(R)-11195 for the 18-kDa translocator protein (TSPO) and… read more here.
Keywords: neurology; pet; disorders review; neuroinflammation neurodegenerative ... See more keywords
The Treatment of Sleep Dysfunction in Neurodegenerative Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00959-7
Abstract: Sleep dysfunction is highly prevalent across the spectrum of neurodegenerative conditions and is a key determinant of quality of life for both patients and their families. Mounting recent evidence also suggests that such dysfunction exacerbates… read more here.
Keywords: dysfunction; sleep dysfunction; neurodegenerative disorders; treatment sleep ... See more keywords
Rethinking IRPs/IRE system in neurodegenerative disorders: Looking beyond iron metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101511
Abstract: Iron regulatory proteins (IRPs) and iron regulatory element (IRE) systems are well known in the progression of neurodegenerative disorders by regulating iron related proteins. IRPs are also regulated by iron homeostasis. However, an increasing number… read more here.
Keywords: irps ire; ire; neurodegenerative disorders; ire system ... See more keywords
Peroxisome proliferator-activated receptors (PPARs) as therapeutic target in neurodegenerative disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.08.043
Abstract: Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors and they serve to be a promising therapeutic target for several neurodegenerative disorders, which includes Parkinson disease, Alzheimer's disease, Huntington disease and Amyotrophic Lateral Sclerosis. PPARs play an… read more here.
Keywords: peroxisome proliferator; proliferator activated; neurodegenerative disorders; activated receptors ... See more keywords
Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.05.003
Abstract: Rapid eye movement (REM) sleep behavior disorder (RBD) involves REM sleep without atonia in conjunction with a recurrent nocturnal dream enactment behavior, with vocalizations such as shouting and screaming, and motor behaviors such as punching… read more here.
Keywords: behavior disorder; rapid eye; eye movement; neurodegenerative disorders ... See more keywords
NAD+ in Brain Aging and Neurodegenerative Disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.09.001
Abstract: NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging… read more here.
Keywords: nad brain; aging neurodegenerative; neurodegenerative disorders; brain ... See more keywords