Mixed Neurodevelopmental and Neurodegenerative Pathology in Nhe6-Null Mouse Model of Christianson Syndrome
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0388-17.2017
Abstract: Abstract Christianson syndrome (CS) is an X-linked disorder resulting from loss-of-function mutations in SLC9A6, which encodes the endosomal Na+/H+ exchanger 6 (NHE6). Symptoms include early developmental delay, seizures, intellectual disability, nonverbal status, autistic features, postnatal… read more here.
Keywords: neurodegenerative pathology; christianson syndrome; pathology; nhe6 null ... See more keywords
Novel Ubiquitin Specific Protease-13 Inhibitors Alleviate Neurodegenerative Pathology
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DOI: 10.3390/metabo11090622
Abstract: Ubiquitin Specific Protease-13 (USP13) promotes protein de-ubiquitination and is poorly understood in neurodegeneration. USP13 is upregulated in Alzheimer’s disease (AD) and Parkinson’s disease (PD), and USP13 knockdown via shRNA reduces neurotoxic proteins and increases proteasome… read more here.
Keywords: specific protease; ubiquitin specific; neurodegenerative pathology; pathology ... See more keywords