Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29058
Abstract: Neurodegenerative proteinopathies are defined as a class of neurodegenerative disorders, with either genetic or sporadic age‐related onset, characterized by the pathological accumulation of aggregated protein deposits. These mainly include Alzheimer's disease (AD), Parkinson's disease (PD),… read more here.
Keywords: neurodegenerative proteinopathies; disease; protein degradation; treat neurodegenerative ... See more keywords
Lymphatic vasculature in human dural superior sagittal sinus: Implications for neurodegenerative proteinopathies
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.11.001
Abstract: Recent reports have characterized functional lymphatic vessels, which drain both fluid and immune cells from the CSF to the deep cervical lymph nodes, lining the dural sinuses in mice. If conserved in the human brain… read more here.
Keywords: neurodegenerative proteinopathies; sagittal sinus; lymphatic vasculature; vasculature human ... See more keywords
Karyopherin abnormalities in neurodegenerative proteinopathies
Sign Up to like & getrecommendations! Published in 2021 at "Brain"
DOI: 10.1093/brain/awab201
Abstract: Abstract Neurodegenerative proteinopathies are characterised by progressive cell loss that is preceded by the mislocalisation and aberrant accumulation of proteins prone to aggregation. Despite their different physiological functions, disease-related proteins like tau, alpha-synuclein, Tar DNA… read more here.
Keywords: karyopherin abnormalities; abnormalities neurodegenerative; accumulation; neurodegenerative proteinopathies ... See more keywords
Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential
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DOI: 10.3390/biomedicines10123000
Abstract: Some of the most prevalent neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease, are proteinopathies characterized by the accumulation of specific protein aggregates in the brain. Such misfolded protein aggregates can trigger modulation of the innate… read more here.
Keywords: cannabinoid cb2; receptors neurodegenerative; proteinopathies new; neurodegenerative proteinopathies ... See more keywords