Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12372
Abstract: Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of… read more here.
Keywords: carcinomas gastrointestinal; neuroendocrine carcinomas; genomic characterization; characterization reveals ... See more keywords
HPV‐associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic features of a rare entity
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22075
Abstract: The majority of human papillomavirus (HPV)–associated oropharyngeal carcinomas are squamous cell carcinomas; however, there are rare reports of HPV–associated neuroendocrine carcinomas (HPV‐NECs) in the upper aerodigestive tract. The aim of this study was to characterize… read more here.
Keywords: neuroendocrine carcinomas; hpv; associated neuroendocrine; hpv associated ... See more keywords
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Breast Cancer"
DOI: 10.1016/j.clbc.2018.09.001
Abstract: Micro‐Abstract Neuroendocrine breast cancer lacks specific therapy, but similar common neuroendocrine carcinomas may offer guidance for therapy development. This study, for the first time, identified several biomarkers for targeted therapy approaches in patients with breast… read more here.
Keywords: neuroendocrine carcinomas; novel; breast nec; breast ... See more keywords
Update on Neuroendocrine Carcinomas of the Larynx.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqz106
Abstract: OBJECTIVES Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of… read more here.
Keywords: neuroendocrine carcinomas; update neuroendocrine; classification; diagnosis ... See more keywords
Everolimus in Pancreatic Neuroendocrine Carcinomas G3
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DOI: 10.1097/mpa.0000000000000762
Abstract: Objective The aim of this study was to investigate everolimus efficacy in well-moderately differentiated pancreatic NEC (pNEC) G3. Methods This was a retrospective analysis of patients with pNEC G3 and Ki67 20% to 55% treated… read more here.
Keywords: neuroendocrine carcinomas; pancreatic neuroendocrine; survival months; oncology ... See more keywords
Clinicopathological characteristics and prognostic factors of patients with primary gallbladder neuroendocrine carcinomas
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.13088
Abstract: Primary gallbladder neuroendocrine carcinomas (GB‐NEC) are malignant neoplasms that remained to be studied. In this study we aimed to summarize their clinicopathological characteristics, effective treatment and prognostic factors for patients with GB‐NEC. read more here.
Keywords: primary gallbladder; prognostic factors; neuroendocrine carcinomas; clinicopathological characteristics ... See more keywords
Efficacy of first‐line checkpoint inhibitors in combination with chemotherapy in high‐grade extrapulmonary metastatic neuroendocrine carcinomas
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.13283
Abstract: Poorly differentiated extrapulmonary neuroendocrine carcinomas (EP NECs) are aggressive cancers characterized by a high Ki‐67 index, rapid tumor growth and poor survival, and are subdivided into small and large cell carcinoma. For small cell carcinoma… read more here.
Keywords: checkpoint; neuroendocrine carcinomas; ctx; first line ... See more keywords
Grading of Neuroendocrine Carcinomas: Correlation of 68Ga-PET/CT Scan with Tissue Biomarkers
Sign Up to like & getrecommendations! Published in 2018 at "Disease Markers"
DOI: 10.1155/2018/6878409
Abstract: There is a growing need for more accurate biomarkers to facilitate the diagnosis and prognosis of patients with grade (G) 3 neuroendocrine carcinomas (NECs). In particular, the discrimination between well-differentiated neuroendocrine carcinomas (WD-NECs) and poorly… read more here.
Keywords: neuroendocrine carcinomas; 68ga pet; expression; loss ... See more keywords
Combined use of albumin and neutrophil-to-lymphocyte ratio as new prognostic and predictive factor in patients with poorly differentiated neuroendocrine carcinomas.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15543
Abstract: e15543Background: Outcomes of patients affected by advanced neuroendocrine carcinomas (NEC) with Ki-67 labeling index > 55% are heterogeneous regardless of the primary tumor site. We explored basel... read more here.
Keywords: neuroendocrine carcinomas; use albumin; neutrophil lymphocyte; carcinomas ... See more keywords
Prognosis for Poorly Differentiated, High-Grade Rectal Neuroendocrine Carcinomas
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DOI: 10.1245/s10434-021-11016-8
Abstract: Rectal neuroendocrine carcinomas (rNECs) are poorly characterized and, given their aggressive nature, optimal management is not well-established. We therefore sought to describe clinicopathologic traits, treatment details, and survival patterns for patients with rNECs. Patients captured… read more here.
Keywords: neuroendocrine carcinomas; chemotherapy; surgical resection; rectal neuroendocrine ... See more keywords
Prevalence, Associated Factors, and Survival Outcomes of Small-Cell Neuroendocrine Carcinoma of the Gynecologic Tract: A Large Population-Based Analysis
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DOI: 10.3389/fmed.2022.836910
Abstract: Small-cell carcinomas are highly malignant tumors with neuroendocrine function and which often occur in the lungs. Primary small-cell neuroendocrine carcinomas of the gynecologic tract are extremely rare. This study aimed to evaluate the prevalence of… read more here.
Keywords: small cell; neuroendocrine carcinomas; cell neuroendocrine; carcinoma ... See more keywords