ADT with antiandrogens in prostate cancer induces adverse effect of increasing resistance, neuroendocrine differentiation and tumor metastasis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.09.020
Abstract: Prostate cancer (PCa) is the most common cancer and the 2nd leading cause of cancer-related deaths among men in the United States. Androgen-deprivation-therapy (ADT) with antiandrogens to target the androgens/androgen receptor (AR) signals remains the… read more here.
Keywords: neuroendocrine differentiation; prostate cancer; resistance; cancer ... See more keywords
Programmed Death Ligand 1 (PD‐L1) Status and Tumor‐Infiltrating Lymphocytes in Hot Spots of Primary and Liver Metastases in Prostate Cancer With Neuroendocrine Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Genitourinary Cancer"
DOI: 10.1016/j.clgc.2018.12.007
Abstract: Background: Prostate cancer with neuroendocrine differentiation (NEPCA) shares similarities in tumor biology with small‐cell lung cancer. While immunotherapies were successfully tested in small‐cell lung cancer, and programmed death ligand 1 (PD‐L1) expression arises as an… read more here.
Keywords: neuroendocrine differentiation; liver metastases; prostate cancer; programmed death ... See more keywords
Breast cancer with neuroendocrine differentiation: an update based on the latest WHO classification
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00736-7
Abstract: Breast cancers with neuroendocrine (NE) differentiation are very heterogeneous, comprising broadly cancers that are morphologically similar to NE tumors (NET) of other anatomic sites, infiltrating breast carcinomas, no special type (IBC-NST) and other special subtypes… read more here.
Keywords: breast cancers; neuroendocrine differentiation; latest classification; breast ... See more keywords
Sweat-gland carcinoma with neuroendocrine differentiation (SCAND): a clinicopathologic study of 13 cases with genetic analysis
Sign Up to like & getrecommendations! Published in 2021 at "Modern Pathology"
DOI: 10.1038/s41379-021-00921-8
Abstract: Low-grade neuroendocrine carcinoma of the skin (LGNECS) was proposed in 2017 as a new primary cutaneous neoplasm with neuroendocrine differentiation; however, it is not yet well known due to its rarity. Herein, we perform a… read more here.
Keywords: neuroendocrine differentiation; gland carcinoma; sweat gland; carcinoma neuroendocrine ... See more keywords
Sox2 is necessary for androgen ablation-induced neuroendocrine differentiation from Pten null Sca-1+ prostate luminal cells
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01526-2
Abstract: Prostate adenocarcinoma undergoes neuroendocrine differentiation to acquire resistance toward antihormonal therapies. The underlying mechanisms have been investigated extensively, among which Sox2 has been shown to play a critical role. However, genetic evidence in mouse models… read more here.
Keywords: neuroendocrine differentiation; induced neuroendocrine; ablation; prostate luminal ... See more keywords
177Lu-PSMA and 177Lu-DOTATATE Therapy in a Patient With Metastatic Castration-Resistant Prostate Cancer and Neuroendocrine Differentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000002824
Abstract: We presented a promising result of radionuclide therapy using Lu-PSMA and Lu-DOTATATE in a patient with prostatic adenocarcinoma and neuroendocrine differentiation. Functional imaging of somatostatin receptors in patients with metastatic castration-resistant prostate cancer may pave… read more here.
Keywords: castration resistant; prostate; metastatic castration; prostate cancer ... See more keywords
Neuroendocrine differentiation in the setting of prostatic carcinoma: contemporary assessment of a consecutive series
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14707
Abstract: Clinicopathologic characterisation of a contemporary series of neuroendocrine (NE) differentiation in the setting of prostatic carcinoma (PCa) was examined. read more here.
Keywords: differentiation setting; series; neuroendocrine differentiation; setting prostatic ... See more keywords
Primary poorly differentiated carcinoma of the vagina with focal neuroendocrine differentiation: a tumour with aggressive behaviour
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2021-247554
Abstract: Primary vaginal neuroendocrine tumours are extremely rare but aggressive. We report a case of primary poorly differentiated vaginal carcinoma with focal neuroendocrine differentiation. The clinical stage was cT3N1M0, FIGO stage III. The patient received six… read more here.
Keywords: neuroendocrine differentiation; carcinoma; primary poorly; poorly differentiated ... See more keywords
ACTH-secreting metastatic prostate cancer with neuroendocrine differentiation
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Case Reports"
DOI: 10.1136/bcr-2021-247997
Abstract: Cushing’s syndrome (CS) due to ectopic adrenocorticotropic hormone (ACTH) secretion (EAS) can result from a variety of tumours and rarely from those of prostatic origin. We present a male patient in his early 60s with… read more here.
Keywords: neuroendocrine differentiation; acth secreting; metastatic prostate; secreting metastatic ... See more keywords
Abstract 1577: GRK3 is a direct target of ADT-induced CREB1 activation and it promotes neuroendocrine differentiation of prostate cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1577
Abstract: Treatment-related neuroendocrine prostate cancer (t-NEPC) is an aggressive subtype of prostate cancer that is believed to arise through neuroendocrine differentiation (NED) from prostate adenocarcinoma (PAC) upon castration resistance to androgen deprivation treatment (ADT). t-NEPC is… read more here.
Keywords: neuroendocrine differentiation; prostate cancer; grk3; creb1 activation ... See more keywords
Abstract 2141: Stromal SPARC deficiency skews prostate cancer toward neuroendocrine differentiation
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2141
Abstract: Tumor progression is a multifaceted process in which, complex interactions between tumor and different types of stromal cells and extracellular matrix components, actively contribute to its phenotypic heterogeneity. Among extracellular matrix proteins, secreted protein acidic… read more here.
Keywords: neuroendocrine differentiation; prostate cancer; stromal sparc; differentiation ... See more keywords