A highly sensitive screening system to evaluate the reversibility of neuroendocrine prostate cancer to prostate adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70047
Abstract: Lineage plasticity in prostate cancer primarily induces transdifferentiation of adenocarcinoma into neuroendocrine prostate cancer (NEPC). Lineage alteration is largely driven by epigenome and is potentially reversible. Nonetheless, evidence supporting NEPC reversibility is lacking in materials… read more here.
Keywords: cancer; highly sensitive; neuroendocrine prostate; prostate ... See more keywords
Patient-derived xenograft models of neuroendocrine prostate cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.004
Abstract: In recent years, patient-derived xenografts (PDXs) have attracted much attention as clinically relevant models for basic and translational cancer research. PDXs retain the principal histopathological and molecular heterogeneity of their donor tumors and remain stable… read more here.
Keywords: xenograft models; prostate cancer; derived xenograft; neuroendocrine prostate ... See more keywords
SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0343-5
Abstract: The mechanisms underlying the lineage switching from prostate adenocarcinoma (AdPC) to lethal neuroendocrine prostate cancer (NEPC) have yet to be completely elucidated. In this study, RNA sequencing data from a unique patient-derived xenograft NEPC model… read more here.
Keywords: prostate; prostate cancer; neuroendocrine prostate; sox2 ... See more keywords
Targeting endoplasmic reticulum stress and nitroso-redox imbalance in neuroendocrine prostate cancer: the therapeutic role of nitric oxide
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02774-5
Abstract: Neuroendocrine prostate cancer (NEPC) is an aggressive and therapy-resistant subtype of prostate cancer characterized by high levels of endoplasmic reticulum (ER) stress and metabolic dysregulation. The subsequential metabolic adaptations in the cancer cells reinforce survival… read more here.
Keywords: cancer; neuroendocrine prostate; stress; prostate cancer ... See more keywords
ONECUT2 is a driver of neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08133-6
Abstract: Neuroendocrine prostate cancer (NEPC), a lethal form of the disease, is characterized by loss of androgen receptor (AR) signaling during neuroendocrine transdifferentiation, which results in resistance to AR-targeted therapy. Clinically, genomically and epigenetically, NEPC resembles… read more here.
Keywords: hypoxia; hypoxia signaling; neuroendocrine prostate; prostate cancer ... See more keywords
Delta-like ligand 3–targeted radioimmunotherapy for neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203820119
Abstract: Significance Neuroendocrine prostate cancer (NEPC) is a highly aggressive variant of prostate cancer with few meaningful treatment options. As a result, patients have a poor prognosis once diagnosis is confirmed. NEPC expresses a unique protein… read more here.
Keywords: prostate cancer; prostate; neuroendocrine prostate; like ligand ... See more keywords
Addressing the need for more therapeutic options in neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Anticancer Therapy"
DOI: 10.1080/14737140.2023.2173174
Abstract: ABSTRACT Introduction Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer frequently seen after prolonged treatment of castration resistant prostate cancer (CRPC). NEPC has become increasingly prevalent over the last 20 years, with… read more here.
Keywords: prostate; neuroendocrine prostate; prostate cancer; treatment options ... See more keywords
The third symposium on treatment-induced neuroendocrine prostate cancer: insights and future directions.
Sign Up to like & getrecommendations! Published in 2024 at "Epigenomics"
DOI: 10.1080/17501911.2024.2391729
Abstract: Neuroendocrine prostate cancer (NEPC) is a rare and aggressive subtype of prostate cancer (PCa), emerging from advanced treatments and characterized by loss of androgen receptor (AR) signaling and neuroendocrine features, leading to rapid progression and… read more here.
Keywords: treatment; prostate cancer; third symposium; neuroendocrine prostate ... See more keywords
Selective Actionable and Druggable Protein Kinases Drive the Progression of Neuroendocrine Prostate Cancer
Sign Up to like & getrecommendations! Published in 2018 at "DNA and Cell Biology"
DOI: 10.1089/dna.2018.4193
Abstract: Current clinical anti-androgen therapies in advanced prostate cancer (PCa) are driving an increased incidence of neuroendocrine prostate cancer (NEPC), a histological variant exhibiting reduced androgen receptor levels and expression of neuroendocrine markers. The mechanisms underlying… read more here.
Keywords: protein; prostate cancer; actionable druggable; neuroendocrine prostate ... See more keywords
Treatment outcome after sequential chemotherapy with cisplatin-etoposide, amrubicin and nogitecan in patients with treatment-related pure small-cell neuroendocrine prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyad011
Abstract: OBJECTIVE This study retrospectively reviewed the clinical characteristics and treatment outcomes of patients with histologically diagnosed treatment-related pure small-cell neuroendocrine prostate cancer. METHODS We retrospectively evaluated data for 13 patients with treatment-related neuroendocrine prostate cancer… read more here.
Keywords: prostate cancer; neuroendocrine prostate; treatment related; treatment ... See more keywords
PD59-01 INSM1 IS A DRIVER OF NEUROENDOCRINE PROSTATE CANCER
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000969.01
Abstract: INTRODUCTION AND OBJECTIVE: Neuroendocrine prostate cancer (NEPC), arising mostly from adenocarcinoma via NE transdifferentiation following androgen deprivation therapy, is a lethal subtype of prostate cancer (PCa). Mechanisms contributing to NEPC development and its aggressiveness remain… read more here.
Keywords: nepc; insm1; prostate; neuroendocrine prostate ... See more keywords