Focused ultrasound as a novel strategy for Alzheimer disease therapeutics
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.24933
Abstract: There is an urgent need to develop novel and effective treatments for Alzheimer disease (AD). Despite decades of advances in genetics and imaging, we are no further in influencing its inexorable decline to functional dependence… read more here.
Keywords: focused ultrasound; alzheimer disease; disease; ultrasound novel ... See more keywords
Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery"
DOI: 10.1080/10717544.2020.1762262
Abstract: Abstract It is reported that quercetin (Que) can prevent tau pathology and induce neuroprotection by improving cognitive and functional symptoms in the treatment of Alzheimer’s disease (AD). However, its clinical application has been limited due… read more here.
Keywords: tau; brain delivery; que; neurofibrillary tangles ... See more keywords
Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.876019
Abstract: Background Cholinergic drugs are the most commonly used drugs for the treatment of Alzheimer’s disease (AD). Therefore, a better understanding of the cholinergic system and its relation to both AD-related biomarkers and cognitive functions is… read more here.
Keywords: cholinergic enzymes; neurofibrillary tangles; tau; neurodegeneration ... See more keywords
A Novel Automatic Quantification Protocol for Biomarkers of Tauopathies in the Hippocampus and Entorhinal Cortex of Post-Mortem Samples Using an Extended Semi-Siamese U-Net
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11081131
Abstract: Simple Summary Tauopathies is a term coined to describe an umbrella of disorders characterized by abnormal Tau polypeptide deposits in neurons, glial cells, and extracellular space. In this work, we propose a novel quantification protocol… read more here.
Keywords: neurofibrillary tangles; quantification; novel automatic; quantification protocol ... See more keywords
Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors
Sign Up to like & getrecommendations! Published in 2023 at "Biosensors"
DOI: 10.3390/bios13020151
Abstract: The identification of protein aggregates as biomarkers for neurodegeneration is an area of interest for disease diagnosis and treatment development. In this work, we present novel super luminescent conjugated polyelectrolyte molecules as ex vivo sensors… read more here.
Keywords: vitro vivo; neurofibrillary tangles; brain; brain sections ... See more keywords
Beyond Amyloid: A Machine Learning-Driven Approach Reveals Properties of Potent GSK-3β Inhibitors Targeting Neurofibrillary Tangles
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25052646
Abstract: Current treatments for Alzheimer’s disease (AD) focus on slowing memory and cognitive decline, but none offer curative outcomes. This study aims to explore and curate the common properties of active, drug-like molecules that modulate glycogen… read more here.
Keywords: amyloid machine; machine learning; machine; targeting neurofibrillary ... See more keywords
Trans- and Cis-Phosphorylated Tau Protein: New Pieces of the Puzzle in the Development of Neurofibrillary Tangles in Post-Ischemic Brain Neurodegeneration of the Alzheimer’s Disease-like Type
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25063091
Abstract: Recent evidence indicates that experimental brain ischemia leads to dementia with an Alzheimer’s disease-like type phenotype and genotype. Based on the above evidence, it was hypothesized that brain ischemia may contribute to the development of… read more here.
Keywords: tau protein; alzheimer disease; neurofibrillary tangles; brain ... See more keywords