Integrated Analysis of Droxidopa for the Treatment of Neurogenic Orthostatic Hypotension in Patients with Parkinson Disease
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DOI: 10.1002/mdc3.12695
Abstract: Neurogenic orthostatic hypotension (nOH) is associated with neurodegenerative conditions, may cause symptoms of end‐organ hypoperfusion, increases fall risk, and can negatively impact quality of life. Droxidopa is approved for the treatment of symptomatic nOH in… read more here.
Keywords: treatment; parkinson disease; droxidopa; orthostatic hypotension ... See more keywords
Epidural Spinal Cord Stimulation to Treat Neurogenic Orthostatic Hypotension in Multiple System Atrophy: A New Hope?
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13583
Abstract: Multiple system atrophy (MSA) is a neurodegenerative movement disorder clinically characterized by a combination of different degrees of parkinsonism, cerebellar ataxia, and autonomic dysfunction. MSA is rapidly progressive, leading patients to be wheelchair bound within… read more here.
Keywords: orthostatic hypotension; neurogenic orthostatic; hypotension; multiple system ... See more keywords
Cerebellar impairment during an orthostatic challenge in patients with neurogenic orthostatic hypotension
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2018.07.026
Abstract: OBJECTIVE Compare activation patterns within the cortical autonomic network in patients with neurogenic orthostatic hypotension (NOH) versus healthy age-matched controls during an orthostatic challenge. METHODS Fifteen health controls and 15 NOH patients performed 3 Valsalva… read more here.
Keywords: orthostatic hypotension; neurogenic orthostatic; patients neurogenic; orthostatic challenge ... See more keywords
Neurogenic Orthostatic Hypotension. Lessons From Synucleinopathies.
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DOI: 10.1093/ajh/hpaa131
Abstract: Maintenance of upright blood pressure critically depends on the autonomic nervous system and its failure leads to neurogenic orthostatic hypotension (NOH). The most severe cases are seen in neurodegenerative disorders caused by abnormal α-synuclein deposits:… read more here.
Keywords: lessons synucleinopathies; treatment; hypotension lessons; orthostatic hypotension ... See more keywords
Cognitive and Behavioral Changes in Patients Treated With Droxidopa for Neurogenic Orthostatic Hypotension: A Retrospective Review
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DOI: 10.1097/wnn.0000000000000198
Abstract: Background: Droxidopa is a norepinephrine precursor that improves symptoms of neurogenic orthostatic hypotension in conditions such as Parkinson disease, multiple system atrophy, and pure autonomic failure by inducing a pressor effect. Unlike other pressor agents,… read more here.
Keywords: patients treated; cognitive behavioral; orthostatic hypotension; treated droxidopa ... See more keywords
Neurogenic orthostatic hypotension after treatment with sorafenib
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DOI: 10.1136/bcr-2021-247140
Abstract: A man in his 70s with a history of fatigue, abdominal pain, and a palpable abdominal mass was found to have a peritoneal desmoid tumour. One year after diagnosis, he was prescribed sorafenib to limit… read more here.
Keywords: orthostatic hypotension; neurogenic orthostatic; hypotension; hypotension treatment ... See more keywords
Droxidopa Persistence in Neurogenic Orthostatic Hypotension May Be Affected by Titration Approach
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DOI: 10.2147/ijgm.s304012
Abstract: Abstract Droxidopa is approved for the treatment of neurogenic orthostatic hypotension (nOH) symptoms and requires patients to be titrated to individualized effective doses (100–600 mg, three times daily) based on symptomatic response. As per the… read more here.
Keywords: persistence; maintenance; droxidopa; titration ... See more keywords
Genetics of Neurogenic Orthostatic Hypotension in Parkinson’s Disease, Results from a Cross-Sectional In Silico Study
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DOI: 10.3390/brainsci13030506
Abstract: The genetic basis of Neurogenic Orthostatic Hypotension (NOH) in Parkinson’s disease (PD) has been inadequately explored. In a cross-sectional study, we examined the association between NOH and PD-related single-nucleotide polymorphisms (SNPs) and mapped their effects… read more here.
Keywords: orthostatic hypotension; neurogenic orthostatic; parkinson disease; cross sectional ... See more keywords