In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.683
Abstract: Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in a pre‐symptomatic carrier of the… read more here.
Keywords: neuroinflammation; carrier; pre symptomatic; mapt mutation ... See more keywords
Reply to the Letter “COVID‐19‐Associated Encephalopathy and Cytokine‐Mediated Neuroinflammation”
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25856
Abstract: Muccioli et al proposed an interesting comparison between the case of encephalitis related to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) infection we described and immune effector cell-associated neurotoxicity syndrome (ICANS). Indeed, the clinical phenotype characterized… read more here.
Keywords: cytokine; reply letter; neuroinflammation; covid ... See more keywords
Circ‐Bnc2 alleviates neuroinflammation in LPS‐stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR‐497a‐5p/HECTD1 axis
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2935
Abstract: Neuroinflammation caused by microglia cells activation and the apoptosis of neuron cells are associated with the occurrence of depression. Circ‐Bnc2 has been shown to be significantly downregulated in depression mice, but its role in the… read more here.
Keywords: neuroinflammation; bnc2 alleviates; circ bnc2; alleviates neuroinflammation ... See more keywords
In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23326
Abstract: In vivo positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChRs) is a promising tool for the imaging evaluation of neurologic and neurodegenerative diseases. However, the role of α7 nAChRs after brain diseases such… read more here.
Keywords: imaging nicotinic; vivo; cerebral ischemia; neuroinflammation ... See more keywords
Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24120
Abstract: Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize… read more here.
Keywords: th1 cells; oligodendrocytes regulate; neuroinflammation; adhesion ... See more keywords
Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
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DOI: 10.1002/glia.24234
Abstract: Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death. Mice lacking NDUFS4, a mitochondrial complex I subunit (Ndufs4 KO mice), have been established as a good animal model for studying human… read more here.
Keywords: ndufs4 mice; neuroinflammation; disease; pathology ... See more keywords
Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes
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DOI: 10.1002/glia.24235
Abstract: Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS) supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested as the main causes of ODC damage during neuroinflammation as observed in multiple sclerosis… read more here.
Keywords: oxidation; eae; neuroinflammation; odc mitochondria ... See more keywords
IGF1R expression by adult oligodendrocytes is not required in the steady‐state but supports neuroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24299
Abstract: In the central nervous system (CNS), insulin‐like growth factor 1 (IGF‐1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti‐apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work… read more here.
Keywords: neuroinflammation; igf1r expression; odcs; absence igf1r ... See more keywords
Pterostilbene inhibits amyloid‐β‐induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase‐1 inflammasome pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27023
Abstract: Neuroinflammation has been known as an important pathogenetic contributor of Alzheimer's disease (AD). Pterostilbene is a natural compound which has neuroprotective activity. However, the effect of pterostilbene on amyloid‐β (Aβ)‐induced neuroinflammation has not been clarified.… read more here.
Keywords: nlrp3 caspase; caspase inflammasome; neuroinflammation; induced neuroinflammation ... See more keywords
miR‐194 relieve neuropathic pain and prevent neuroinflammation via targeting FOXA1
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29598
Abstract: The emerging role of microRNAs (miRNAs) have been deeply explored in multiple diseases including neuropathic pain. miR‐194 was widely reported to be a tumor suppressor and was related to the inflammatory response. The critical role… read more here.
Keywords: 194 neuropathic; neuroinflammation; neuropathic pain; via targeting ... See more keywords
Mycobacterium tuberculosis causes a leaky blood‐brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10116
Abstract: The maternal system's exposure to pathogens influences foetal brain development through the influx of maternal cytokines and activation of the foetal immune status to a persistent inflammatory state characterised by glia cell activation. Neuroinflammation influences… read more here.
Keywords: blood brain; mtb; neuroinflammation; tuberculosis ... See more keywords