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   Articles with "neuroinflammation" as a keyword



In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier

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recommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.683

Abstract: Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in a pre‐symptomatic carrier of the… read more here.

Keywords: neuroinflammation; carrier; pre symptomatic; mapt mutation ... See more keywords

CpG and Rutin Co‐Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition

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recommendations! Published in 2024 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202403469

Abstract: Intracerebral hemorrhage (ICH) presents a formidable challenge due to its high mortality and disability rates, primarily attributed to cerebral hematoma formation and ensuing neuroinflammation. Swift hematoma removal is paramount for prognosis, yet existing interventions carry… read more here.

Keywords: neuroinflammation; intracerebral hemorrhage; hematoma; hematoma clearance ... See more keywords

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202503972

Abstract: Activation of microglia is closely associated with neuroinflammation. However, the cell‐intrinsic molecular mechanisms translating microglia activation into neuroinflammation are only partially understood. Here, it is shown that deubiquitinating enzyme A (DUBA) is upregulated in microglia… read more here.

Keywords: irak1; regulation neuroinflammation; neuroinflammation; activation ... See more keywords
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Reply to the Letter “COVID‐19‐Associated Encephalopathy and Cytokine‐Mediated Neuroinflammation”

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recommendations! Published in 2020 at "Annals of Neurology"

DOI: 10.1002/ana.25856

Abstract: Muccioli et al proposed an interesting comparison between the case of encephalitis related to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2) infection we described and immune effector cell-associated neurotoxicity syndrome (ICANS). Indeed, the clinical phenotype characterized… read more here.

Keywords: cytokine; reply letter; neuroinflammation; covid ... See more keywords

Circ‐Bnc2 alleviates neuroinflammation in LPS‐stimulated microglial cells to inhibit neuron cell apoptosis through regulating miR‐497a‐5p/HECTD1 axis

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recommendations! Published in 2023 at "Brain and Behavior"

DOI: 10.1002/brb3.2935

Abstract: Neuroinflammation caused by microglia cells activation and the apoptosis of neuron cells are associated with the occurrence of depression. Circ‐Bnc2 has been shown to be significantly downregulated in depression mice, but its role in the… read more here.

Keywords: neuroinflammation; bnc2 alleviates; circ bnc2; alleviates neuroinflammation ... See more keywords

Progress in the Pathogenesis of Diabetic Encephalopathy: The Key Role of Neuroinflammation

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recommendations! Published in 2024 at "Diabetes/Metabolism Research and Reviews"

DOI: 10.1002/dmrr.3841

Abstract: Diabetic encephalopathy (DE) is a severe complication that occurs in the central nervous system (CNS) and leads to cognitive impairment. DE involves various pathophysiological processes, and its pathogenesis is still unclear. This review summarised current… read more here.

Keywords: neuroinflammation; pathogenesis diabetic; progress pathogenesis; research ... See more keywords

In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia

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recommendations! Published in 2018 at "Glia"

DOI: 10.1002/glia.23326

Abstract: In vivo positron emission tomography (PET) imaging of nicotinic acetylcholine receptors (nAChRs) is a promising tool for the imaging evaluation of neurologic and neurodegenerative diseases. However, the role of α7 nAChRs after brain diseases such… read more here.

Keywords: imaging nicotinic; vivo; cerebral ischemia; neuroinflammation ... See more keywords

Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation.

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recommendations! Published in 2021 at "Glia"

DOI: 10.1002/glia.24120

Abstract: Recently, oligodendrocytes (Ol) have been attributed potential immunomodulatory effects. Yet, the exact mode of interaction with pathogenic CNS infiltrating lymphocytes remains unclear. Here, we attempt to dissect mechanisms of Ol modulation during neuroinflammation and characterize… read more here.

Keywords: th1 cells; oligodendrocytes regulate; neuroinflammation; adhesion ... See more keywords

Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24234

Abstract: Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death. Mice lacking NDUFS4, a mitochondrial complex I subunit (Ndufs4 KO mice), have been established as a good animal model for studying human… read more here.

Keywords: ndufs4 mice; neuroinflammation; disease; pathology ... See more keywords

Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24235

Abstract: Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS) supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested as the main causes of ODC damage during neuroinflammation as observed in multiple sclerosis… read more here.

Keywords: oxidation; eae; neuroinflammation; odc mitochondria ... See more keywords

IGF1R expression by adult oligodendrocytes is not required in the steady‐state but supports neuroinflammation

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recommendations! Published in 2022 at "Glia"

DOI: 10.1002/glia.24299

Abstract: In the central nervous system (CNS), insulin‐like growth factor 1 (IGF‐1) regulates myelination by oligodendrocyte (ODC) precursor cells and shows anti‐apoptotic properties in neuronal cells in different in vitro and in vivo systems. Previous work… read more here.

Keywords: neuroinflammation; igf1r expression; odcs; absence igf1r ... See more keywords