Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01784-6
Abstract: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder in which superior brain functions, such as memory and cognition, are impaired. Currently, no effective treatment is available for AD. Although andrographolide (ANDRO), a compound extracted from… read more here.
Keywords: neuroinflammation oxidative; aged octodon; oxidative stress; stress ... See more keywords
Depletion of brain perivascular macrophages regulates acute restraint stress-induced neuroinflammation and oxidative/nitrosative stress in rat frontal cortex
Sign Up to like & getrecommendations! Published in 2020 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.03.004
Abstract: The central nervous system can respond to peripheral immune stimuli through the activation of the neurovascular unit. One of the cellular types implicated are perivascular macrophages (PVMs), hematopoietic-derived brain-resident cells located in the perivascular space.… read more here.
Keywords: neuroinflammation oxidative; induced neuroinflammation; stress induced; stress ... See more keywords
Magnolol abrogates chronic mild stress‐induced depressive‐like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.03.031
Abstract: ABSTRACT Magnolol, the main constituent of Magnolia officinalis, has been shown to produce antidepressant‐like effect in rodents. Growing evidence shows that neuroinflammation, oxidative stress and neuroendocrine contribute to the pathogenesis of major depression. Here, the… read more here.
Keywords: neuroinflammation oxidative; magnolol; depressive like; stress ... See more keywords
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00744
Abstract: Perioperative neurocognitive disorder (PND) is a common adverse event after surgical trauma in elderly patients. The pathogenesis of PND is still unclear. Adiponectin (APN) is a plasma protein secreted by adipose tissue. We have reported… read more here.
Keywords: cognitive deficits; neuroinflammation oxidative; apn; tlr4 ... See more keywords
Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacology"
DOI: 10.1159/000520990
Abstract: Aim: Recent evidence indicates that neuroinflammation and oxidative stress play vital roles in the pathological process of major depressive disorder (MDD). Cinnamic acid (CA), a naturally occurring organic acid, has been reported to ameliorate neuroinflammation… read more here.
Keywords: like behaviors; stress; oxidative stress; neuroinflammation oxidative ... See more keywords
Antidepressant-like effect of a new selenium-containing compound is accompanied by a reduction of neuroinflammation and oxidative stress in lipopolysaccharide-challenged mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881117711713
Abstract: Organoselenium compounds and indoles have gained attention due to their wide range of pharmacological properties. Depression is a recurrent and disabling psychiatric illness and current evidences support that oxidative stress and neuroinflammation are mechanisms underlying… read more here.
Keywords: neuroinflammation oxidative; effect; cmi; stress ... See more keywords
Ampelopsin improves cognitive impairment in Alzheimer's disease and involvement of neuroinflammation and oxidative stress in the hippocampus.
Sign Up to like & getrecommendations! Published in 2019 at "Current Alzheimer research"
DOI: 10.2174/1567205016666191203153447
Abstract: BACKGROUND Neuroinflammation and oxidative stress have important effects on cognitive functions in the pathophysiological process of Alzheimer's disease (AD). In the current study, we determined the effects of Ampelopsin (AMP) on the levels of proinflammatory… read more here.
Keywords: neuroinflammation oxidative; hippocampus; alzheimer disease; stress ... See more keywords
Crosstalk between neuroinflammation and oxidative stress in epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.976953
Abstract: The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy have begun to receive considerable attention in recent years. However, these concepts are predominantly studied as separate entities despite the evidence that… read more here.
Keywords: stress; oxidative stress; crosstalk neuroinflammation; neuroinflammation oxidative ... See more keywords
Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.856914
Abstract: Excessive dietary salt intake induces neuroinflammation and oxidative stress in the brain, which lead to sympathetic excitation, contributing to hypertension. However, the underlying mechanisms remain elusive. Accumulating evidence reveals that trimethylamine-N-oxide (TMAO), a gut microbiota-derived… read more here.
Keywords: stress; oxidative stress; neuroinflammation oxidative; sympathetic excitation ... See more keywords
Kinin B1 Receptor Mediates Bidirectional Interaction between Neuroinflammation and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12010150
Abstract: Hypertension is associated with increased expression of kinin B1 receptors (B1R) and increased levels of pro-inflammatory cytokines within the neurons. We previously reported that angiotensin II (Ang II) upregulates B1R expression and can induce neuroinflammation… read more here.
Keywords: stress; b1r; oxidative stress; neuroinflammation oxidative ... See more keywords
Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032642
Abstract: Neuroinflammation and oxidative stress have been emerging as important pathways contributing to Parkinson’s disease (PD) pathogenesis. In PD brains, the activated microglia release inflammatory factors such as interleukin (IL)-β, IL-6, tumor necrosis factor (TNF)-α, and… read more here.
Keywords: stress; oxidative stress; investigating therapeutic; parkinson disease ... See more keywords