Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.11.008
Abstract: Previous studies have demonstrated a close association between an altered immune system and major depressive disorders, and inhibition of neuroinflammation may represent an alternative mechanism to treat depression. Recently, the anti-inflammatory activity of ibrutinib has… read more here.
Keywords: depression; ibrutinib; lps induced; neuroinflammation ... See more keywords
Effect of sildenafil on neuroinflammation and synaptic plasticity pathways in experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106581
Abstract: Multiple sclerosis (MS) is a chronic immuno-inflammatory disease of the central nervous system characterized by demyelination and axonal damage. Cognitive changes are common in individuals with MS since inflammatory molecules secreted by microglia interfere with… read more here.
Keywords: neuroinflammation synaptic; synaptic plasticity; effect sildenafil; plasticity ... See more keywords