Regulatory Effects of Neuroinflammatory Responses Through Brain-Derived Neurotrophic Factor Signaling in Microglial Cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-0933-z
Abstract: Inhibition of microglial over-activation is an important strategy to counter balance neurodegenerative progression. We previously demonstrated that the adenosine monophosphate-activated protein kinase (AMPK) may be a therapeutic target in mediating anti-neuroinflammatory responses in microglia. Brain-derived… read more here.
Keywords: neuroinflammatory responses; brain derived; derived neurotrophic; neuroinflammation ... See more keywords
HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00148-1
Abstract: Paraquat (PQ), a widely characterized neurotoxicant, has been generally accepted as one of the environmental factors in the etiology of Parkinson’s disease (PD). Despite the direct evidence that PQ could induce inflammatory responses in central… read more here.
Keywords: neuroinflammatory responses; activating rage; via activating; signaling pathway ... See more keywords
Involvement of progranulin in modulating neuroinflammatory responses but not neurogenesis in the hippocampus of aged mice
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2017.05.003
Abstract: Abstract It is well established that adult neurogenesis in the hippocampus declines with age. Our previous studies have suggested that progranulin (PGRN) has a facilitative effect on hippocampal neurogenesis. We have also shown that PGRN… read more here.
Keywords: neuroinflammatory responses; hippocampus; neurogenesis; age ... See more keywords
The taste of neuroinflammation: molecular mechanisms linking taste sensing to neuroinflammatory responses.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105557
Abstract: Evidence indicates a critical role of neuroinflammatory response as an underlying pathophysiological process in several central nervous system disorders, including neurodegenerative diseases. However, the molecular mechanisms that trigger neuroinflammatory processes are not fully known. The… read more here.
Keywords: taste; neuroinflammatory responses; taste receptor; molecular mechanisms ... See more keywords
PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-022-02398-x
Abstract: Background Tissue damage and cellular destruction are the major events in traumatic brain injury (TBI), which trigger sterile neuroimmune and neuroinflammatory responses in the brain. While appropriate acute and transient neuroimmune and neuroinflammatory responses facilitate… read more here.
Keywords: damage; neuroimmune neuroinflammatory; neuroinflammatory responses; traumatic brain ... See more keywords
Heterogeneity of Neuroinflammatory Responses in Amyotrophic Lateral Sclerosis: A Challenge or an Opportunity?
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21217923
Abstract: Amyotrophic Lateral Sclerosis (ALS) is a complex pathology: (i) the neurodegeneration is chronic and progressive; it starts focally in specific central nervous system (CNS) areas and spreads to different districts; (ii) multiple cell types further… read more here.
Keywords: neuroinflammatory responses; amyotrophic lateral; responses amyotrophic; heterogeneity neuroinflammatory ... See more keywords