Truncation of neurokinin‐1 receptor—Negative regulation of substance P signaling
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mir0817-348r
Abstract: Substance P (SP) is a tachykinin peptide, which triggers intracellular signaling in the nervous and immune systems, as well as, other local and systemic events. The interaction between SP and its receptor, neurokinin‐1 receptor (NK1R),… read more here.
Keywords: substance; neurokinin receptor; truncation neurokinin; activation ... See more keywords
Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Revista Brasileira De Anestesiologia"
DOI: 10.1016/j.bjane.2020.06.015
Abstract: Summary Background Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5-Hydroxytryptamine3 (5-HT3) receptor antagonists and Neurokinin-1 (NK-1) receptor antagonists, have been used to treat PONV. Objectives… read more here.
Keywords: neurokinin receptor; systematic review; receptor antagonists; receptor ... See more keywords
Synthesis and Evaluation of a Novel 64Cu- and 67Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00063
Abstract: Neurokinin 1 receptor (NK1R) is expressed in gliomas and neuroendocrine malignancies and represents a promising target for molecular imaging and targeted radionuclide therapy. The goal of this study was to synthesize and evaluate a novel… read more here.
Keywords: targeting nk1r; neurokinin receptor; 67ga labeled; nk1r nota ... See more keywords
Development of a Ligand-Targeted Therapeutic Agent for Neurokinin-1 Receptor Expressing Cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00583
Abstract: The neurokinin-1 receptor (NK1R) plays a significant role in the progression and metastasis of several neuroendocrine tumors. Due to its upregulation in these cancers, NK1R constitutes an attractive receptor for development of ligand-targeted imaging and… read more here.
Keywords: development ligand; ligand targeted; neurokinin receptor; receptor ... See more keywords
Neurokinin-1 receptor antagonists: review of their role for the prevention of chemotherapy-induced nausea and vomiting in adults
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2019.1621162
Abstract: ABSTRACT Introduction: The addition of neurokinin-1 receptor antagonists (NK1RAs) to standard prophylaxis of 5-hydroxytryptamine-3 RA (5-HT3RA) plus dexamethasone more effectively prevents chemotherapy-induced nausea and vomiting (CINV) associated with highly and moderately emetogenic chemotherapy. Areas covered:… read more here.
Keywords: chemotherapy; neurokinin receptor; induced nausea; chemotherapy induced ... See more keywords
A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain.
Sign Up to like & getrecommendations! Published in 2017 at "Pain"
DOI: 10.1097/j.pain.0000000000000919
Abstract: Thoracotomy results in chronic postoperative pain (CPTP) in half of the cases. Earlier findings in rat models of persistent post-surgical pain suggest that spinal pathways are critical for pain onset but not its maintenance. Descending… read more here.
Keywords: pain role; pain; neurokinin receptor;
The overexpression of neurokinin B–neurokinin 3 receptor system exerts direct effects on the ovary under PCOS‐like conditions to interfere with mitochondrial function
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13663
Abstract: The increased hypothalamic neurokinin B (NKB) level may contribute to the hyperactive LH pulse secretion in Polycystic ovary syndrome (PCOS). However, the expression and role of the neurokinin B‐neurokinin 3 receptor (NKB‐NK3R) system in the… read more here.
Keywords: system; neurokinin receptor; overexpression neurokinin; neurokinin ... See more keywords
Substance P and neurokinin 1 receptor are new targets for the treatment of chronic pruritus
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18025
Abstract: Chronic pruritus is a distressing symptom associated with various dermatological conditions and systemic diseases. Current treatment options are often inadequate, resulting in impaired quality of life for many patients. An understanding of the underlying mechanisms… read more here.
Keywords: neurokinin receptor; substance neurokinin; receptor new; treatment ... See more keywords
Dihydroavenanthramide D inhibits mast cell degranulation and exhibits anti‐inflammatory effects through the activation of neurokinin‐1 receptor
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13265
Abstract: Chronic pruritus is difficult to treat. Current treatment options are frequently ineffective and new therapeutic approaches are urgently needed. Avenanthramides are active substances in oats that exhibit anti‐inflammatory effects. Their potential to interrupt pruritus mechanisms… read more here.
Keywords: anti inflammatory; neurokinin receptor; cell degranulation; mast cell ... See more keywords
A Substance P (SP)/Neurokinin-1 Receptor Axis Promotes Perineural Invasion of Pancreatic Cancer and Is Affected by lncRNA LOC389641
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/5582811
Abstract: Perineural invasion (PNI) is considered to be a main reason for the poor prognosis of pancreatic cancer. In the present study, we analyzed the roles of substance P (SP)/neurokinin-1 receptor (NK-1R) and lncRNA LOC389641 in… read more here.
Keywords: neurokinin receptor; pancreatic cancer; pni; invasion ... See more keywords
Factors associated with neurokinin-1 receptor antagonist use among commercially insured cancer patients receiving highly emetogenic chemotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.5_suppl.24
Abstract: 24Background: Neurokinin-1 receptor antagonists (NK1RA) reduce chemotherapy-induced nausea/vomiting (CINV) among patients undergoing highly emetogenic chemotherapy (HEC). We evaluated factors associated with the use of NK1RA in patients treated with HEC. Methods: We performed a retrospective… read more here.
Keywords: chemotherapy; use; neurokinin receptor; factors associated ... See more keywords