Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases.
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DOI: 10.1002/adma.201801362
Abstract: Therapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood-brain barrier (BBB), arguably the most tightly regulated interface in the human body, which… read more here.
Keywords: blood brain; brain; neurological diseases; brain barrier ... See more keywords
Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019
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DOI: 10.1002/ana.26041
Abstract: Patients with coronavirus disease 2019 (COVID‐19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)‐2, IL‐4, IL‐6, IL‐10, IL‐12, chemokine (C‐X‐C motif) ligand… read more here.
Keywords: cytokine patterns; patterns associated; disease 2019; inflammatory cytokine ... See more keywords
Targeting Inflammasomes to Treat Neurological Diseases
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DOI: 10.1002/ana.26158
Abstract: Inflammasomes are multimeric protein complexes that can sense a plethora of microbe‐ and damage‐associated molecular signals. They play important roles in innate immunity and are key regulators of inflammation in health and disease. Inflammasome‐mediated processing… read more here.
Keywords: inflammasomes treat; inflammasome activation; disease; targeting inflammasomes ... See more keywords
The Role of Chimeric Antigen Receptor T‐Cell Therapy in Immune‐Mediated Neurological Diseases
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DOI: 10.1002/ana.27029
Abstract: Despite the use of ‘high efficacy’ disease‐modifying therapies, disease activity and clinical progression of different immune‐mediated neurological diseases continue for some patients, resulting in accumulating disability, deteriorating social and mental health, and high economic cost… read more here.
Keywords: immune mediated; therapy; neurological diseases; mediated neurological ... See more keywords
Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases
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DOI: 10.1002/ana.27157
Abstract: Cerebrospinal fluid (CSF) provides unique insights into the brain and neurological diseases. However, the potential of CSF flow cytometry applied on a large scale remains unknown. read more here.
Keywords: immune cells; cerebrospinal fluid; neurological diseases; fluid immune ... See more keywords
Tubulin deacetylase NDST3 modulates lysosomal acidification: Implications in neurological diseases
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200110
Abstract: Neurological diseases (NDs), featured by progressive dysfunctions of the nervous system, have become a growing burden for the aging populations. N‐Deacetylase and N‐sulfotransferase 3 (NDST3) is known to catalyze deacetylation and N‐sulfation on disaccharide substrates.… read more here.
Keywords: neurological diseases; lysosomal acidification; deacetylase; tubulin deacetylase ... See more keywords
The neuroprotective effect and possible therapeutic application of xenon in neurological diseases.
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DOI: 10.1002/jnr.24958
Abstract: Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The… read more here.
Keywords: neuroprotective effect; xenon; neurological diseases; possible therapeutic ... See more keywords
A concise review of the orofacial mesenchymal stromal cells as a novel therapy for neurological diseases and injuries
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3333
Abstract: Orofacial mesenchymal stromal cells (OFMSCs) are mesenchymal stromal cells isolated from the oral and facial regions, which possess typical mesenchymal stromal cell features such as self‐renewing, multilineage differentiation, and immunoregulatory properties. Recently, increasing studies have… read more here.
Keywords: concise review; neurological diseases; mesenchymal stromal; orofacial mesenchymal ... See more keywords
Bridging the Metabolic Parallels Between Neurological Diseases and Cancer.
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DOI: 10.1007/978-3-030-65768-0_17
Abstract: Despite the many recent breakthroughs in cancer research, oncology has traditionally been seen as a distinct field from other diseases. Recently, more attention has been paid to repurposing established therapeutic strategies and targets of other… read more here.
Keywords: metabolic parallels; cancer neurological; metabolic overlap; bridging metabolic ... See more keywords
[Frequent neurological diseases associated with the restless legs syndrome].
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DOI: 10.1007/s00115-018-0528-y
Abstract: BACKGROUND Restless legs syndrome (RLS) is a common neurological disease. Studies have shown that RLS is associated with a variety of medical and neurological disorders. OBJECTIVES Using the example of three associated neurological diseases, the significance for… read more here.
Keywords: frequent neurological; prevalence; neurological diseases; legs syndrome ... See more keywords
[Antisense therapies for neurological diseases].
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DOI: 10.1007/s00115-019-0724-4
Abstract: Despite identification of many genes causing neurodegenerative diseases in the last decades, development of disease-modifying treatments has been slow. Antisense oligonucleotide (ASO) therapeutics for spinal muscular atrophy, Duchenne muscular dystrophy and transthyretin amyloidosis predict a robust… read more here.
Keywords: medicine; neurological diseases; antisense therapies; therapies neurological ... See more keywords