Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies
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DOI: 10.1038/s41598-020-64862-z
Abstract: Antecedent viral infection may contribute to increased susceptibility to several neurological diseases, such as multiple sclerosis and Parkinson’s disease. Variation in clinical presentations of these diseases is often associated with gender, genetic background, or a… read more here.
Keywords: presentation; collaborative cross; disease; neurological phenotypes ... See more keywords
Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19
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DOI: 10.1038/s41598-021-99481-9
Abstract: Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we… read more here.
Keywords: hospitalized covid; characterization neurological; neurological phenotypes; patients hospitalized ... See more keywords
The determinants of neurological phenotypes during acute hypertensive crises – a preliminary study
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DOI: 10.1080/01616412.2020.1735121
Abstract: ABSTRACT Background and Purpose: Acute blood pressure elevations lead to wide spectrum of neurologic manifestations, ranging from no overt neurologic symptoms to catastrophic events like ICH. Little is known regarding the determinants of this clinical… read more here.
Keywords: patients normal; normal neurological; determinants neurological; neurological examination ... See more keywords
Variable neurological phenotypes of homocystinuria caused by biallelic methylenetetrahydrofolate reductase variants
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DOI: 10.1097/mcd.0000000000000407
Abstract: Inherited methylenetetrahydrofolate reductase (MTHFR) deficiency is associated with a wide spectrum of disorders including homocystinuria. This study aims to describe the neurological phenotypes and molecular profiles of patients with homocystinuria caused by biallelic variants in… read more here.
Keywords: homocystinuria caused; neurological phenotypes; variable neurological; methylenetetrahydrofolate reductase ... See more keywords
Neurological Phenotypes in Mouse Models of Mitochondrial Disease and Relevance to Human Neuropathology
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DOI: 10.3390/ijms24119698
Abstract: Mitochondrial diseases represent the most common inherited neurometabolic disorders, for which no effective therapy currently exists for most patients. The unmet clinical need requires a more comprehensive understanding of the disease mechanisms and the development… read more here.
Keywords: models mitochondrial; mouse models; neurological phenotypes; mitochondrial disease ... See more keywords