Discovery of First-in-Class Peptidomimetic Neurolysin Activators Possessing Enhanced Brain Penetration and Stability.
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DOI: 10.1021/acs.jmedchem.1c00759
Abstract: Peptidase neurolysin (Nln) is an enzyme that functions to cleave various neuropeptides. Upregulation of Nln after stroke has identified the enzyme as a critical endogenous cerebroprotective mechanism and validated target for the treatment of ischemic… read more here.
Keywords: discovery; neurolysin; brain penetration; nln ... See more keywords