Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29683-w
Abstract: Neuromedin U receptors (NMURs), including NMUR1 and NMUR2, are a group of Gq/11-coupled G protein-coupled receptors (GPCRs). NMUR1 and NMUR2 play distinct, pleiotropic physiological functions in peripheral tissues and in the central nervous system (CNS),… read more here.
Keywords: neuromedin receptors; activation; nmur1 nmur2; structural insights ... See more keywords
Differential effects of selective agonists of neuromedin U1 and U2 receptors in obese and diabetic mice
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14077
Abstract: Neuromedin U (NmU) may be a novel target for obesity treatment owing to its anorectic and energy expenditure enhancing effects. Although two receptors, NMU1 and NMU2, are both responsible for the NmU‐mediated anti‐obesity effects, the… read more here.
Keywords: selective agonists; differential effects; neuromedin receptors; receptors obese ... See more keywords