Advances in In vitro Models of Neuromuscular Junction: Focusing on Organ-on-a-chip, Organoids and Biohybrid Robotics.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211059
Abstract: The neuromuscular junction (NMJ) is a peripheral synaptic connection between presynaptic motor neurons and postsynaptic skeletal muscle fibers that enables muscle contraction and voluntary motor movement. Many traumatic, neurodegenerative and neuroimmunological diseases are classically believed… read more here.
Keywords: neuromuscular junction; organ chip; robotics; organoids biohybrid ... See more keywords
Compensatory neuromuscular junction adaptations of forelimb muscles in focal cortical ischemia in rats
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DOI: 10.1002/brb3.1472
Abstract: Upper limb movements are affected frequently by brain ischemia (BI). Mechanisms involved in recovery and compensatory movements have developed several studies. However, less attention is given to skeletal muscles, where neuromuscular junction (NMJ) has an… read more here.
Keywords: compensatory neuromuscular; ischemia; neuromuscular junction; junction adaptations ... See more keywords
Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila
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DOI: 10.1002/dneu.22681
Abstract: The coordinated growth and development of synapses is critical for all aspects of neural circuit function and mutations that disrupt these processes can result in various neurological defects. Several anterograde and retrograde signaling pathways, including… read more here.
Keywords: tao; bmp signaling; tao negatively; negatively regulates ... See more keywords
nPKCε Mediates SNAP-25 Phosphorylation of Ser-187 in Basal Conditions and After Synaptic Activity at the Neuromuscular Junction
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DOI: 10.1007/s12035-018-1462-5
Abstract: Protein kinase C (PKC) and substrates like SNAP-25 regulate neurotransmission. At the neuromuscular junction (NMJ), PKC promotes neurotransmitter release during synaptic activity. Thirty minutes of muscle contraction enhances presynaptic PKC isoform levels, specifically cPKCβI and… read more here.
Keywords: snap phosphorylation; synaptic activity; ser 187; neuromuscular junction ... See more keywords
Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis
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DOI: 10.1007/s12035-021-02658-6
Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier studies have shown that motor neuron degeneration begins in motor cortex and descends… read more here.
Keywords: lateral sclerosis; neuromuscular junction; amyotrophic lateral; motor ... See more keywords
Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.014
Abstract: The neuromuscular junction (NMJ) is formed by motor nerve terminals, post-junctional muscle membranes, and terminal Schwann cells (SCs). The formation of NMJ requires complex and dynamic molecular interactions. Nerve- and muscle-derived molecules have been well… read more here.
Keywords: pten egfr; specific pten; neuromuscular junction; development ... See more keywords
Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics.
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DOI: 10.1016/j.biomaterials.2018.02.047
Abstract: There are currently no functional neuromuscular junction (hNMJ) systems composed of human cells that could be used for drug evaluations or toxicity testing in vitro. These systems are needed to evaluate NMJs for diseases such as… read more here.
Keywords: dose response; response; cell derived; stem cell ... See more keywords
Bioengineered optogenetic model of human neuromuscular junction.
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DOI: 10.1016/j.biomaterials.2021.121033
Abstract: Functional human tissues engineered from patient-specific induced pluripotent stem cells (hiPSCs) hold great promise for investigating the progression, mechanisms, and treatment of musculoskeletal diseases in a controlled and systematic manner. For example, bioengineered models of… read more here.
Keywords: optogenetic model; model human; human neuromuscular; bioengineered optogenetic ... See more keywords
Causes and consequences of age-related changes at the neuromuscular junction
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DOI: 10.1016/j.cophys.2018.04.007
Abstract: Sarcopenia is the age-related loss of muscle mass and function and has a major impact on quality of life. The neuromuscular junction (NMJ) appears to be a major focal point of age-related perturbations. Many morphological… read more here.
Keywords: age related; age; consequences age; causes consequences ... See more keywords
Recent insights into neuromuscular junction biology in Duchenne muscular dystrophy: Impacts, challenges, and opportunities
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DOI: 10.1016/j.ebiom.2020.103032
Abstract: Duchenne muscular dystrophy (DMD) is the most common and relentless form of muscular dystrophy. The pleiotropic effects of dystrophin deficiency include remarkable impacts on neuromuscular junction (NMJ) structure and function. Some of these alterations contribute… read more here.
Keywords: dmd; muscular dystrophy; biology; neuromuscular junction ... See more keywords
α−Calcitonin gene-related peptide inhibits autophagy and calpain systems and maintains the stability of neuromuscular junction in denervated muscles
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DOI: 10.1016/j.molmet.2019.06.024
Abstract: Objective Although it is well established that a-calcitonin gene-related peptide (CGRP) stabilizes muscle-type cholinergic receptors nicotinic subunits (AChR), the underlying mechanism by which this neuropeptide regulates muscle protein metabolism and neuromuscular junction (NMJ) morphology is… read more here.
Keywords: autophagy calpain; related peptide; gene related; calcitonin gene ... See more keywords