Functional adaptation of glial cells at neuromuscular junctions in response to injury
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24184
Abstract: Synaptic elements from neuromuscular junctions (NMJs) undergo massive morphological and functional changes upon nerve injury. While morphological changes of NMJ‐associated glia in response to injury has been investigated, their functional properties remain elusive. Perisynaptic Schwann… read more here.
Keywords: adaptation; response injury; neuromuscular junctions; glial cells ... See more keywords
Early differences in membrane properties at the neuromuscular junctions of ALS model mice: Effects of 25-hydroxycholesterol.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119300
Abstract: AIMS Plasma hyperlipidemia is a protective factor in amyotrophic lateral sclerosis (ALS) while cholesterol-lowering drugs aggravate the pathology. We hypothesize that this phenomenon can be linked with membrane lipid alterations in the neuromuscular junctions (NMJs)… read more here.
Keywords: raft; membrane properties; ceramide; neuromuscular junctions ... See more keywords
Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions.
Sign Up to like & getrecommendations! Published in 2020 at "Cell stem cell"
DOI: 10.1016/j.stem.2020.01.003
Abstract: Stem cell technology enables the production of three-dimensional organ-like structures, but engineering multi-tissue anatomy has proven difficult. In this issue of Cell Stem Cell, Martins et al. (2020) show that generating a common progenitor cell for… read more here.
Keywords: develop motor; motor skills; stem cell; organoids develop ... See more keywords
In vitro models of neuromuscular junctions and their potential for novel drug discovery and development
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2020.1700225
Abstract: ABSTRACT Introduction: Neuromuscular Junctions (NMJs) are the synapses between motor neurons and skeletal muscle fibers, and they are responsible for voluntary motor function. NMJs are affected at early stages of numerous neurodegenerative and neuroimmunological diseases.… read more here.
Keywords: vitro models; drug; drug discovery; neuromuscular junctions ... See more keywords
Age‐related changes in the structure and function of mammalian neuromuscular junctions
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.13521
Abstract: As mammals age, their neuromuscular junctions (NMJs) change their form, with an increasingly complex system of axonal branches innervating increasingly fragmented regions of postsynaptic differentiation. It has been suggested that this remodeling is associated with… read more here.
Keywords: age related; age; function; neuromuscular junctions ... See more keywords
Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.166978
Abstract: Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral palsy, which anticipates the typical spastic paralysis… read more here.
Keywords: brainstem nuclei; neuromuscular junctions; cephalic tetanus; tetanus ... See more keywords
Expression and Roles of Lynx1, a Modulator of Cholinergic Transmission, in Skeletal Muscles and Neuromuscular Junctions in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.838612
Abstract: Lynx1 is a glycosylphosphatidylinositol (GPI)-linked protein shown to affect synaptic plasticity through modulation of nicotinic acetylcholine receptor (nAChR) subtypes in the brain. Because of this function and structural similarity to α-bungarotoxin, which binds muscle-specific nAChRs… read more here.
Keywords: muscles neuromuscular; expression roles; lynx1; neuromuscular junctions ... See more keywords
“Calcium bombs” as harbingers of synaptic pathology and their mitigation by magnesium at murine neuromuscular junctions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.937974
Abstract: Excitotoxicity is thought to be an important factor in the onset and progression of amyotrophic lateral sclerosis (ALS). Evidence from human and animal studies also indicates that early signs of ALS include degeneration of motor… read more here.
Keywords: degeneration; neuromuscular junctions; calcium bombs; synaptic pathology ... See more keywords
Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses
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DOI: 10.3390/biom12020179
Abstract: Synaptic transmission is essential for controlling motor functions and maintaining brain functions such as walking, breathing, cognition, learning, and memory. Neurotransmitter release is regulated by presynaptic molecules assembled in active zones of presynaptic terminals. The… read more here.
Keywords: presynaptic molecules; diversity presynaptic; neuromuscular junctions; similarity diversity ... See more keywords
The Structure of Human Neuromuscular Junctions: Some Unanswered Molecular Questions
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18102183
Abstract: The commands that control animal movement are transmitted from motor neurons to their target muscle cells at the neuromuscular junctions (NMJs). The NMJs contain many protein species whose role in transmission depends not only on… read more here.
Keywords: junctions unanswered; transmitter; human neuromuscular; structure ... See more keywords
Early Alterations in Structural and Functional Properties in the Neuromuscular Junctions of Mutant FUS Mice
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109022
Abstract: Amyotrophic lateral sclerosis (ALS) is manifested as skeletal muscle denervation, loss of motor neurons and finally severe respiratory failure. Mutations of RNA-binding protein FUS are one of the common genetic reasons of ALS accompanied by… read more here.
Keywords: neuromuscular junctions; mutant fus; neurotransmitter release; structural functional ... See more keywords