Prenatal hyperhomocysteinemia induces oxidative stress and accelerates ‘aging’ of mammalian neuromuscular synapses
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Developmental Neuroscience"
DOI: 10.1016/j.ijdevneu.2019.03.004
Abstract: Enhanced levels of homocysteine during pregnancy induce oxidative stress and contribute to many age‐related diseases. In this study, we analyzed age‐dependent synaptic modifications in developing neuromuscular synapses of rats with prenatal hyperhomocysteinemia (hHCY). One of… read more here.
Keywords: hhcy; neuromuscular synapses; oxidative stress; prenatal hyperhomocysteinemia ... See more keywords
Vezatin is required for the maturation of the neuromuscular synapse
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-06-0313
Abstract: Key genes, such as Agrin, Lrp4, and MuSK, are required for the initial formation, subsequent maturation, and long-term stabilization of mammalian neuromuscular synapses. Additional molecules are thought to function selectively during the evolution and stabilization… read more here.
Keywords: vezatin required; neuromuscular synapses; maturation; vezatin ... See more keywords